Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | CDK7 | P50613 | 1/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11229121 | 0.88 | MEN1 (0.41) | ATMMEN1KMT2AKDM4ELMNA | |
| SCHEMBL11222288 | 0.81 | MEN1 (0.40) | ATMMEN1KMT2AKDM4ELMNA | |
| SCHEMBL11231103 | 0.74 | MERTK (0.38) | KDM4EAPOBEC3AAPOBEC3GSIGMAR1 | |
| SCHEMBL11231701 | 0.70 | PABPC1 (0.51) | ATMMEN1KMT2AKDM4ELMNA | |
| SCHEMBL11236486 | 0.67 | ATM (0.44) | ATMMEN1KMT2AKDM4EMAPT | |
| SCHEMBL11231889 | 0.66 | KDM4E (0.49) | MEN1KMT2AKDM4ELMNAMAPT | |
| SCHEMBL11227000 | 0.65 | ATM (0.42) | ATMKDM4EMAPTCASP1CASP7 | |
| SCHEMBL11226073 | 0.65 | ATM (0.45) | ATMKDM4EMAPTCASP1CASP7 | |
| SCHEMBL11238184 | 0.63 | MAPK10 (0.43) | MEN1KMT2AKDM4ELMNAMAPT | |
| SCHEMBL17316881 | 0.62 | PIK3CG (0.53) | MAPTPIK3CGPIK3CDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4361568-A | 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridin-3-amines and their cardiotonic use | STERLING DRUG INC. (US) | 1982-11-30 | — | — | US | disclosed |
| EP-0063754-A1 | Pyrazolopyridine derivatives, and preparation, useful as cardiotonics | STERLING DRUG INC. (US) | 1982-11-03 | — | — | EP | disclosed |