Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 4/20 | 0.45 |
| ▸ | CASP1 | P29466 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | APOBEC3A | P31941 | 3/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 3/20 | 0.41 |
| ▸ | GSK3A | P49840 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.40 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11227000 | 0.90 | ATM (0.42) | ATMCASP1ALDH1A1APOBEC3AAPOBEC3G | |
| SCHEMBL11232136 | 0.82 | LATS1 (0.38) | CASP1ALDH1A1GSK3AGSK3BIKBKE | |
| SCHEMBL11222288 | 0.81 | MEN1 (0.40) | ATMCASP1ALDH1A1GSK3AGSK3B | |
| SCHEMBL11233210 | 0.78 | MEN1 (0.43) | ATMCASP1ALDH1A1GSK3AGSK3B | |
| SCHEMBL11231701 | 0.78 | PABPC1 (0.51) | ATMCASP1ALDH1A1GSK3AGSK3B | |
| SCHEMBL11226000 | 0.77 | GSK3B (0.49) | CASP1ALDH1A1GSK3BIKBKETBK1 | |
| SCHEMBL11238837 | 0.74 | DYRK1A (0.36) | CASP1ALDH1A1GSK3BIKBKETBK1 | |
| SCHEMBL11236571 | 0.72 | NR1D1 (0.33) | CASP1ALDH1A1GSK3AGSK3BAXL | |
| SCHEMBL11280195 | 0.72 | GSK3B (0.37) | ATMCASP1ALDH1A1APOBEC3AAPOBEC3G | |
| SCHEMBL11231889 | 0.72 | KDM4E (0.49) | CASP1ALDH1A1GSK3AGSK3BAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4361568-A | 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridin-3-amines and their cardiotonic use | STERLING DRUG INC. (US) | 1982-11-30 | — | — | US | disclosed |
| EP-0063754-A1 | Pyrazolopyridine derivatives, and preparation, useful as cardiotonics | STERLING DRUG INC. (US) | 1982-11-03 | — | — | EP | disclosed |