Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 9/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | ACP3 | P15309 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.36 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL342226 | 0.84 | ALDH1A1 (0.38) | KMT2AMAPTHTT | |
| SCHEMBL14895887 | 0.71 | CYP19A1 (0.44) | KIF11CYP19A1MEN1KMT2ASCN5A | |
| SCHEMBL3362675 | 0.70 | CYP19A1 (0.40) | KIF11CYP19A1MEN1KMT2ASCN5A | |
| SCHEMBL11475760 | 0.69 | KIF11 (0.40) | KIF11NPC1RAB9ACYP19A1MEN1 | |
| SCHEMBL28838841 | 0.69 | KIF11 (0.47) | KIF11SCN5ASCN9A | |
| SCHEMBL10876037 | 0.68 | CYP19A1 (0.42) | KIF11CYP19A1SCN5ASCN9A | |
| SCHEMBL1561509 | 0.68 | MEN1 (0.42) | KIF11CYP19A1MEN1KMT2ASCN5A | |
| SCHEMBL23279616 | 0.68 | CYP19A1 (0.39) | KIF11CYP19A1MEN1KMT2AMAPT | |
| SCHEMBL604099 | 0.68 | NPSR1 (0.39) | KIF11NPC1RAB9ACYP19A1KMT2A | |
| SCHEMBL11624026 | 0.68 | CYP19A1 (0.42) | KIF11NPC1RAB9AACP3CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4327228-A | 3-Nitro-1-phenyl-1-(m-chlorophenyl)-propan-2-ol. | BEECHAM GROUP LIMITED (GB) | 1982-04-27 | — | — | US | disclosed |
| EP-0022310-A2 | Process for the preparation of 3-dimethylamino-1-phenyl-1-(m-chlorophenyl) propan-2-ol and intermediate for this process | BEECHAM GROUP PLC (GB) | 1981-01-14 | — | — | EP | disclosed |