Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 8/20 | 0.51 |
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.51 |
| ▸ | ESR1 | P03372 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | PGR | P06401 | 3/20 | 0.51 |
| ▸ | AR | P10275 | 3/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9319671 | 1.00 | LMNA (0.51) | LMNAMAPTKMT2ACYP3A4ESR1 | |
| SCHEMBL11247578 | 0.91 | RECQL (0.54) | LMNAMAPTKMT2ACYP3A4ESR1 | |
| SCHEMBL11234223 | 0.91 | RECQL (0.54) | LMNAMAPTKMT2ACYP3A4ESR1 | |
| SCHEMBL11239668 | 0.91 | KMT2A (0.53) | LMNAMAPTKMT2ACYP3A4ESR1 | |
| SCHEMBL11236592 | 0.91 | KMT2A (0.53) | LMNAMAPTKMT2ACYP3A4ESR1 | |
| SCHEMBL11298268 | 0.90 | ZAP70 (0.49) | LMNAMAPTKMT2ACYP3A4ESR1 | |
| SCHEMBL9319675 | 0.89 | LMNA (0.56) | LMNAMAPTKMT2ACYP3A4ESR1 | |
| SCHEMBL8835854 | 0.89 | LMNA (0.56) | LMNAMAPTKMT2ACYP3A4ESR1 | |
| SCHEMBL8836335 | 0.84 | LMNA (0.58) | LMNAMAPTKMT2ACYP3A4ESR1 | |
| SCHEMBL10406599 | 0.82 | LMNA (0.63) | LMNAMAPTKMT2ACYP3A4ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-55089299-A | — | — | None | — | — | JP | disclosed |
| US-4332797-A | ANTITUMOR AGENTS | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1982-06-01 | — | — | US | disclosed |
| US-4261910-A | COUPLING WITH ESTRADIOL THROUGH DIFUNCTIONAL COMPOUND | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1981-04-14 | — | — | US | disclosed |
| JP-S5589299-A | NOVEL ESTRADIOL DERIVATIVE, ITS PREPARATION, AND ANTITUMOR AGENT | KUREHA CHEM IND CO LTD | 1980-07-05 | — | — | JP | disclosed |