Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.56 |
| ▸ | ESR1 | P03372 | 4/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | ATM | Q13315 | 3/20 | 0.56 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.56 |
| ▸ | SHBG | P04278 | 1/20 | 0.56 |
| ▸ | FYN | P06241 | 1/20 | 0.56 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.56 |
| ▸ | HTR2B | P41595 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | INPPL1 | O15357 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8835854 | 1.00 | LMNA (0.56) | LMNAESR1ADORA3SMN1; SMN2KMT2A | |
| SCHEMBL11247578 | 0.92 | RECQL (0.54) | LMNAESR1ADORA3SMN1; SMN2KMT2A | |
| SCHEMBL11234223 | 0.92 | RECQL (0.54) | LMNAESR1ADORA3SMN1; SMN2KMT2A | |
| SCHEMBL11239668 | 0.92 | KMT2A (0.53) | LMNAESR1ADORA3SMN1; SMN2KMT2A | |
| SCHEMBL11236592 | 0.92 | KMT2A (0.53) | LMNAESR1ADORA3SMN1; SMN2KMT2A | |
| SCHEMBL9319671 | 0.89 | LMNA (0.51) | LMNAESR1ADORA3SMN1; SMN2KMT2A | |
| SCHEMBL11234684 | 0.89 | LMNA (0.51) | LMNAESR1ADORA3SMN1; SMN2KMT2A | |
| SCHEMBL11298268 | 0.88 | ZAP70 (0.49) | LMNAESR1ADORA3SMN1; SMN2KMT2A | |
| SCHEMBL11312360 | 0.87 | ESR1 (0.59) | LMNAESR1ADORA3SMN1; SMN2KMT2A | |
| SCHEMBL8836343 | 0.86 | LMNA (0.58) | LMNAESR1ADORA3SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0300749-B1 | Injectable formulation containing 3-benzoyloxy-1,3,5(10)-estratriene-17-[4-[p-(bis(2-chloroethyl)amino)phenyl]-butanoyloxy]acetate | KUREHA CHEMICAL IND CO LTD (JP) | 1994-01-26 | — | — | EP | claimed |
| US-4921849-A | Injection containing 3-benzoyloxy-1,3,5(10)-estratriene-17-[4-{p-(bis(2-chloroethyl)amino)phenyl}butanoyloxy)acetate as an active ingredient | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1990-05-01 | — | — | US | claimed |
| EP-0300749-A2 | Injectable formulation containing 3-benzoyloxy-1,3,5(10)-estratriene-17-[4-[p-(bis(2-chloroethyl)amino)phenyl]-butanoyloxy]acetate | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1989-01-25 | — | — | EP | claimed |
| EP-0300749-B1 | Injectable formulation containing 3-benzoyloxy-1,3,5(10)-estratriene-17-[4-[p-(bis(2-chloroethyl)amino)phenyl]-butanoyloxy]acetate | KUREHA CHEMICAL IND CO LTD (JP) | 1994-01-26 | — | — | EP | disclosed |
| EP-0300749-B1 | Injectable formulation containing 3-benzoyloxy-1,3,5(10)-estratriene-17-[4-[p-(bis(2-chloroethyl)amino)phenyl]-butanoyloxy]acetate | KUREHA CHEMICAL IND CO LTD (JP) | 1994-01-26 | — | — | EP | disclosed |
| US-4921849-A | Injection containing 3-benzoyloxy-1,3,5(10)-estratriene-17-[4-{p-(bis(2-chloroethyl)amino)phenyl}butanoyloxy)acetate as an active ingredient | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1990-05-01 | — | — | US | disclosed |
| US-4885290-A | ANTIBODY INHIBITION; SURGICAL TRANSPLANTS | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1989-12-05 | — | — | US | disclosed |
| EP-0300749-A2 | Injectable formulation containing 3-benzoyloxy-1,3,5(10)-estratriene-17-[4-[p-(bis(2-chloroethyl)amino)phenyl]-butanoyloxy]acetate | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1989-01-25 | — | — | EP | disclosed |
| EP-0300749-A2 | Injectable formulation containing 3-benzoyloxy-1,3,5(10)-estratriene-17-[4-[p-(bis(2-chloroethyl)amino)phenyl]-butanoyloxy]acetate | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1989-01-25 | — | — | EP | disclosed |
| EP-0300749-A2 | Injectable formulation containing 3-benzoyloxy-1,3,5(10)-estratriene-17-[4-[p-(bis(2-chloroethyl)amino)phenyl]-butanoyloxy]acetate | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1989-01-25 | — | — | EP | disclosed |
| US-4332797-A | ANTITUMOR AGENTS | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1982-06-01 | — | — | US | disclosed |
| US-4261910-A | COUPLING WITH ESTRADIOL THROUGH DIFUNCTIONAL COMPOUND | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1981-04-14 | — | — | US | disclosed |