Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | PAOX | Q6QHF9 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL757198 | 0.95 | TSHR (0.52) | TSHRALDH1A1PAOXCYP2C19CYP1A2 | |
| SCHEMBL10437484 | 0.93 | TSHR (0.43) | TSHRALDH1A1PAOXCYP2C19CYP1A2 | |
| SCHEMBL6658327 | 0.93 | TSHR (0.50) | TSHRALDH1A1PAOXCYP2C19CYP1A2 | |
| SCHEMBL14943785 | 0.93 | TSHR (0.50) | TSHRALDH1A1PAOXCYP2C19CYP1A2 | |
| SCHEMBL755010 | 0.93 | TSHR (0.50) | TSHRALDH1A1PAOXCYP2C19CYP1A2 | |
| SCHEMBL6664307 | 0.93 | TSHR (0.50) | TSHRALDH1A1PAOXCYP2C19CYP1A2 | |
| SCHEMBL755821 | 0.93 | TSHR (0.50) | TSHRALDH1A1PAOXCYP2C19CYP1A2 | |
| SCHEMBL6657028 | 0.93 | TSHR (0.50) | TSHRALDH1A1PAOXCYP2C19CYP1A2 | |
| SCHEMBL15078094 | 0.90 | TDP1 (0.39) | TSHRALDH1A1PAOXCYP2C19CYP1A2 | |
| Hydrochloric Acid SCHEMBL6657314 | 0.88 | ALDH1A1 (0.46) | TSHRALDH1A1PAOXCYP2C19CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4357333-A | N-Substituted 2-(8-halo and trifluoromethyl 4-quinolylamino)benzamides and analgesic use thereof | JOHN WYETH & BROTHER LIMITED (GB) | 1982-11-02 | — | — | US | disclosed |
| EP-0001175-B1 | 4-AMINOQUINOLINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | JOHN WYETH & BROTHER LIMITED (GB) | 1981-04-15 | — | — | EP | disclosed |
| EP-0001175-A1 | 4-Aminoquinoline derivatives, a process for their preparation and pharmaceutical compositions containing them | JOHN WYETH & BROTHER LIMITED (GB) | 1979-03-21 | — | — | EP | disclosed |