SCHEMBL11235159

SCHEMBL11235159

CCOC(=O)C(=O)c1ccc(C2CCCCC2)c(O)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 1/20 0.42
CA1 P00915 1/20 0.42
CA2 P00918 1/20 0.42
CA7 P43166 1/20 0.42
CA9 Q16790 1/20 0.42
CA14 Q9ULX7 1/20 0.42
PTGDR2 Q9Y5Y4 1/20 0.40
ALDH1A1 P00352 6/20 0.39
ALOX15 P16050 1/20 0.39
MAPK1 P28482 1/20 0.39
RAB9A P51151 2/20 0.39
NPC1 O15118 1/20 0.39
POLB P06746 1/20 0.38
HTT P42858 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
HPGD P15428 2/20 0.38
STS P08842 1/20 0.37
TYR P14679 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11243142 0.87 PTGDR2 (0.40) PTGDR2ALDH1A1ALOX15MAPK1RAB9A
SCHEMBL11237838 0.86 ALDH1A1 (0.39) PTGDR2ALDH1A1ALOX15MAPK1RAB9A
SCHEMBL11232893 0.86 ALOX5AP (0.39) PTGDR2ALDH1A1ALOX15MAPK1RAB9A
SCHEMBL11228084 0.86 TP53 (0.41) PTGDR2ALDH1A1ALOX15MAPK1RAB9A
SCHEMBL11229659 0.86 TP53 (0.41) PTGDR2ALDH1A1ALOX15MAPK1RAB9A
SCHEMBL11224527 0.86 ALOX15 (0.49) PTGDR2ALDH1A1ALOX15MAPK1RAB9A
SCHEMBL11231172 0.86 ALDH1A1 (0.39) PTGDR2ALDH1A1ALOX15MAPK1RAB9A
SCHEMBL11233428 0.85 HSD17B2 (0.43) PTGDR2ALDH1A1ALOX15RAB9ANPC1
SCHEMBL11243094 0.84 ALDH1A1 (0.40) PTGDR2ALDH1A1ALOX15MAPK1RAB9A
SCHEMBL11233107 0.84 TSHR (0.42) PTGDR2ALDH1A1ALOX15MAPK1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4365093-A Ethynylbenzene compounds and derivatives thereof WILLIAM H. RORER, INC. (US) 1982-12-21 US disclosed
US-4296264-A Ethynylbenzene compounds and derivatives thereof WILLIAM H. RORER, INC. (US) 1981-10-20 US disclosed
US-4288457-A Ethynylbenzene compounds and derivatives thereof WILLIAM H. RORER, INC. (US) 1981-09-08 US disclosed
US-4264627-A Ethynylbenzene compounds and derivatives thereof to treat inflammation, pain or fever WILLIAM H. RORER, INC. (US) 1981-04-28 US disclosed
US-4171373-A Ethynylbenzene compounds and derivatives thereof to treat pain, fever and inflammation WILLIAM H. RORER, INC. (US) 1979-10-16 US disclosed
US-4168320-A Ethynylbenzene compounds and derivatives thereof to treat inflammation, pain or fever WILLIAM H. RORER, INC. (US) 1979-09-18 US disclosed
US-4166133-A ETHYNYLBENZENE COMPOUNDS AND DERIVATIVES THEREOF TO TREAT PAIN, FEVER AND INFLAMMATION WILLIAM H. RORER, INC. (US) 1979-08-28 US disclosed
US-4157449-A Ethynylbenzene compounds and derivatives thereof WILLIAM H. RORER, INC. (US) 1979-06-05 US disclosed
US-4150148-A NITROSUBSTITUTED WILLIAM H. RORER, INC. (US) 1979-04-17 US disclosed
US-4120889-A Cyano ethynylbenzene compounds WILLIAM H. RORER, INC. (US) 1978-10-17 US disclosed
US-4120885-A Ethynylbenzene compounds and derivatives thereof WILLIAM H. RORER, INC. (US) 1978-10-17 US disclosed
US-4105786-A ANTIINFLAMMATORY WILLIAM H. RORER, INC. (US) 1978-08-08 US disclosed
US-4101591-A Ethynylbenzene compounds and derivatives thereof WILLIAM H. RORER, INC. (US) 1978-07-18 US disclosed
US-4096279-A Ethynylbenzene compounds and derivatives thereof in the treatment of pain fever and inflammation WILLIAM H. RORER, INC. (US) 1978-06-20 US disclosed
US-4094995-A ETHYNYLBENZENE COMPOUNDS AND DERIVATIVES THEREOF TO TREAT PAIN, FEVER AND INFLAMMATION WILLIAM H. RORER, INC. (US) 1978-06-13 US disclosed
US-4093737-A Ethynylbenzene compounds and derivatives thereof in the treatment of pain, fever or inflammation WILLIAM H. RORER, INC. (US) 1978-06-06 US disclosed
US-4075354-A ETHYNYLBENZENE COMPOUNDS AND DERIVATIVES THEREOF FOR TREATING PAIN FEVER AND INFLAMMATION WILLIAM H. RORER, INC. (US) 1978-02-21 US disclosed
US-3981932-A Ethynylbenzene compounds and derivatives thereof WILLIAM H. RORER, INC. (US) 1976-09-21 US disclosed