Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | GALR2 | O43603 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | PDE7A | Q13946 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
| ▸ | PRKCA | P17252 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.39 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.38 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7835308 | 0.86 | GALR2 (0.46) | POLBGALR2LMNANPC1RAB9A | |
| SCHEMBL11241875 | 0.84 | POLB (0.47) | POLBNPC1RAB9APDE7AMAPT | |
| SCHEMBL11235055 | 0.84 | LATS1 (0.40) | POLBMAP2K3MAPK14NPC1RAB9A | |
| SCHEMBL11238719 | 0.84 | GAA (0.47) | POLBNPC1RAB9APDE7AMAPT | |
| SCHEMBL11233319 | 0.80 | L3MBTL1 (0.52) | POLBLMNAPDE7AMAPTPRKCA | |
| SCHEMBL11235434 | 0.79 | PRKCD (0.51) | POLBLMNANPC1RAB9APDE7A | |
| SCHEMBL11231846 | 0.79 | POLB (0.52) | POLBLMNARAB9APDE7AMAPT | |
| SCHEMBL11228112 | 0.78 | L3MBTL1 (0.47) | POLBLMNANPC1RAB9AMAPT | |
| SCHEMBL3652564 | 0.77 | KDR (0.46) | POLBGALR2LMNANPC1RAB9A | |
| SCHEMBL11232737 | 0.76 | PKN1 (0.44) | POLBMAP2K3NPC1RAB9APDE7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4317909-A | Preparation of 1,3-dihydro-5-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones | STERLING DRUG INC. (US) | 1982-03-02 | — | — | US | disclosed |
| US-4294836-A | 1,3-Dihydro-6-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones and -imidazo[4,5-b]-pyridine-2-thiones and their cardiotonic use | STERLING DRUG INC. (US) | 1981-10-13 | — | — | US | disclosed |