Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | LATS1 | O95835 | 2/20 | 0.45 |
| ▸ | LATS2 | Q9NRM7 | 2/20 | 0.45 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NAAA | Q02083 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | STAT1 | P42224 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TXNRD1 | Q16881 | 5/20 | 0.38 |
| ▸ | PRKCA | P17252 | 2/20 | 0.38 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.38 |
| ▸ | GSR | P00390 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11233319 | 0.95 | L3MBTL1 (0.52) | L3MBTL1TP53POLBLATS1LATS2 | |
| SCHEMBL11238719 | 0.85 | GAA (0.47) | L3MBTL1TP53POLBLATS1LATS2 | |
| SCHEMBL11235434 | 0.83 | PRKCD (0.51) | POLBLATS1LATS2LMNAALDH1A1 | |
| SCHEMBL11231846 | 0.82 | POLB (0.52) | POLBHCAR3LMNAALDH1A1MAPT | |
| SCHEMBL11237821 | 0.79 | LATS1 (0.52) | LATS1LATS2LMNAALDH1A1MAPT | |
| SCHEMBL11653146 | 0.79 | MAPT (0.58) | L3MBTL1HCAR3LMNARIPK1ALDH1A1 | |
| SCHEMBL11650084 | 0.79 | L3MBTL1 (0.59) | L3MBTL1POLBHCAR3LMNARIPK1 | |
| SCHEMBL11235404 | 0.78 | POLB (0.45) | POLBLATS1LATS2LMNAALDH1A1 | |
| SCHEMBL9041749 | 0.77 | MAPT (0.59) | L3MBTL1POLBHCAR3LMNARIPK1 | |
| SCHEMBL11237124 | 0.76 | POLB (0.49) | L3MBTL1TP53POLBLATS1LATS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4317909-A | Preparation of 1,3-dihydro-5-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones | STERLING DRUG INC. (US) | 1982-03-02 | — | — | US | disclosed |
| US-4294836-A | 1,3-Dihydro-6-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones and -imidazo[4,5-b]-pyridine-2-thiones and their cardiotonic use | STERLING DRUG INC. (US) | 1981-10-13 | — | — | US | disclosed |