Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Ifoxetine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 4/20 | 0.43 |
| ▸ | SLC6A2 known ✓ | P23975 | 5/20 | 0.38 |
| ▸ | SLC6A4 known ✓ | P31645 | 4/20 | 0.38 |
| ▸ | HTR2C known ✓ | P28335 | 2/20 | 0.35 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.35 |
| ▸ | CTSV | O60911 | 2/20 | 0.38 |
| ▸ | CTSL | P07711 | 2/20 | 0.38 |
| ▸ | CTSB | P07858 | 2/20 | 0.38 |
| ▸ | CTSS | P25774 | 2/20 | 0.38 |
| ▸ | CTSK | P43235 | 2/20 | 0.38 |
| ▸ | CTSC | P53634 | 2/20 | 0.38 |
| ▸ | CTSF | Q9UBX1 | 2/20 | 0.38 |
| ▸ | CTSH | P09668 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ifoxetine SCHEMBL11235529 | 1.00 | HRH1 (0.43) | HRH1CTSVCTSLCTSBCTSS | |
| Ifoxetine SCHEMBL11235528 | 1.00 | HRH1 (0.43) | HRH1CTSVCTSLCTSBCTSS | |
| Ifoxetine SCHEMBL119624 | 0.90 | SLC6A2 (0.42) | CTSVCTSLCTSBCTSSCTSK | |
| Ifoxetine SCHEMBL3961263 | 0.90 | SLC6A2 (0.42) | CTSVCTSLCTSBCTSSCTSK | |
| Ifoxetine SCHEMBL5782634 | 0.90 | SLC6A2 (0.42) | CTSVCTSLCTSBCTSSCTSK | |
| Ifoxetine SCHEMBL3961271 | 0.90 | SLC6A2 (0.42) | CTSVCTSLCTSBCTSSCTSK | |
| Ifoxetine SCHEMBL3959131 | 0.90 | SLC6A2 (0.42) | CTSVCTSLCTSBCTSSCTSK | |
| Ifoxetine SCHEMBL13918626 | 0.90 | SLC6A2 (0.42) | CTSVCTSLCTSBCTSSCTSK | |
| Ifoxetine SCHEMBL3959125 | 0.90 | SLC6A2 (0.42) | CTSVCTSLCTSBCTSSCTSK | |
| Ifoxetine SCHEMBL13918625 | 0.90 | SLC6A2 (0.42) | CTSVCTSLCTSBCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4320137-A | Derivatives of perhydro-aza-heterocycles | CIBA-GEIGY CORPORATION (US) | 1982-03-16 | — | — | US | disclosed |
| US-4246269-A | Antidepressant piperidinones | CIBA-GEIGY CORPORATION (US) | 1981-01-20 | — | — | US | disclosed |
| US-4160837-A | ANTIDEPRESSANTS | CIBA-GEIGY CORPORATION (US) | 1979-07-10 | — | — | US | disclosed |