Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 10/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 3/20 | 0.42 |
| ▸ | CTSV | O60911 | 2/20 | 0.41 |
| ▸ | CTSL | P07711 | 2/20 | 0.41 |
| ▸ | CTSB | P07858 | 2/20 | 0.41 |
| ▸ | CTSS | P25774 | 2/20 | 0.41 |
| ▸ | CTSK | P43235 | 2/20 | 0.41 |
| ▸ | CTSC | P53634 | 2/20 | 0.41 |
| ▸ | CTSF | Q9UBX1 | 2/20 | 0.41 |
| ▸ | CTSH | P09668 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.39 |
| ▸ | CSF1R | P07333 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ifoxetine SCHEMBL13918625 | 1.00 | SLC6A2 (0.42) | SLC6A2HTR1AHTR2CCTSVCTSL | |
| Ifoxetine SCHEMBL13918626 | 1.00 | SLC6A2 (0.42) | SLC6A2HTR1AHTR2CCTSVCTSL | |
| Ifoxetine SCHEMBL5782634 | 1.00 | SLC6A2 (0.42) | SLC6A2HTR1AHTR2CCTSVCTSL | |
| Ifoxetine SCHEMBL119624 | 1.00 | SLC6A2 (0.42) | SLC6A2HTR1AHTR2CCTSVCTSL | |
| Ifoxetine SCHEMBL3959125 | 1.00 | SLC6A2 (0.42) | SLC6A2HTR1AHTR2CCTSVCTSL | |
| Ifoxetine SCHEMBL3961263 | 1.00 | SLC6A2 (0.42) | SLC6A2HTR1AHTR2CCTSVCTSL | |
| Ifoxetine SCHEMBL3959131 | 1.00 | SLC6A2 (0.42) | SLC6A2HTR1AHTR2CCTSVCTSL | |
| Ifoxetine SCHEMBL11235529 | 0.90 | HRH1 (0.43) | SLC6A2HTR1AHTR2CCTSVCTSL | |
| Ifoxetine SCHEMBL11235520 | 0.90 | HRH1 (0.43) | SLC6A2HTR1AHTR2CCTSVCTSL | |
| Ifoxetine SCHEMBL11235528 | 0.90 | HRH1 (0.43) | SLC6A2HTR1AHTR2CCTSVCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4160837-A | ANTIDEPRESSANTS | CIBA-GEIGY CORPORATION (US) | 1979-07-10 | — | — | US | claimed |
| US-8569342-B2 | Diastereomers of 4-aryloxy-3-hydroxypiperidines | BRENTWOOD EQUITIES, LTD. (GB) | 2013-10-29 | — | — | US | disclosed |
| US-8569342-B2 | Diastereomers of 4-aryloxy-3-hydroxypiperidines | BRENTWOOD EQUITIES, LTD. (GB) | 2013-10-29 | — | — | US | disclosed |
| US-8569342-B2 | Diastereomers of 4-aryloxy-3-hydroxypiperidines | BRENTWOOD EQUITIES, LTD. (GB) | 2013-10-29 | — | — | US | disclosed |
| EP-1667972-B1 | DIASTEREOMERS OF 4-ARYLOXY-3-HYDROXYPIPERIDINES | BRENTWOOD EQUITIES LTD (GB) | 2013-06-19 | — | — | EP | disclosed |
| EP-2078027-A1 | CATHEPSIN PROTEASES INHIBITORS | IRM LLC (BM) | 2009-07-15 | — | — | EP | disclosed |
| US-7504419-B2 | Diastereomers of 4-aryloxy-3-hydroxypiperidines | RATTAN BALVINDER SINGH | 2009-03-17 | — | — | US | disclosed |
| US-7504419-B2 | Diastereomers of 4-aryloxy-3-hydroxypiperidines | RATTAN BALVINDER SINGH | 2009-03-17 | — | — | US | disclosed |
| US-7504419-B2 | Diastereomers of 4-aryloxy-3-hydroxypiperidines | RATTAN BALVINDER SINGH | 2009-03-17 | — | — | US | disclosed |
| US-20080287500-A1 | Diastereomers of 4-aryloxy-3-hydroxypiperidines | BRENTWOOD EQUITIES, LTD. | 2008-11-20 | — | — | US | disclosed |
| US-20080287500-A1 | Diastereomers of 4-aryloxy-3-hydroxypiperidines | BRENTWOOD EQUITIES, LTD. | 2008-11-20 | — | — | US | disclosed |
| US-20080287500-A1 | Diastereomers of 4-aryloxy-3-hydroxypiperidines | BRENTWOOD EQUITIES, LTD. | 2008-11-20 | — | — | US | disclosed |
| WO-2008051763-A1 | CATHEPSIN PROTEASES INHIBITORS | IRM LLC (BM) | 2008-05-02 | — | — | WO | disclosed |
| US-20050203136-A1 | Diastereomers of 4-aryloxy-3-hydroxypiperidines | RATTAN BALVINDER S (GB) | 2005-09-15 | — | — | US | disclosed |
| US-4320137-A | Derivatives of perhydro-aza-heterocycles | CIBA-GEIGY CORPORATION (US) | 1982-03-16 | — | — | US | disclosed |
| US-4246269-A | Antidepressant piperidinones | CIBA-GEIGY CORPORATION (US) | 1981-01-20 | — | — | US | disclosed |
| US-4160837-A | ANTIDEPRESSANTS | CIBA-GEIGY CORPORATION (US) | 1979-07-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050203136-A1 | Diastereomers of 4-aryloxy-3-hydroxypiperidines | HTR2C, HTR4, HTR5A | SLC6A2 34/4885HTR1A 12/4885HTR2C 1/4885 |
| US-20080287500-A1 | Diastereomers of 4-aryloxy-3-hydroxypiperidines | HTR2C, HTR4, HTR5A | SLC6A2 34/4885HTR1A 12/4885HTR2C 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.