Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR1E | P28566 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1777187 | 0.84 | KDM4E (0.40) | KDM4EPKMLMNAKMT2AMEN1 | |
| SCHEMBL17445904 | 0.76 | PDK2 (0.46) | KDM4EPKMLMNAKMT2AALDH1A1 | |
| SCHEMBL11090567 | 0.76 | KDM4E (0.71) | KDM4EPKMLMNAKMT2AALDH1A1 | |
| SCHEMBL1780625 | 0.75 | KDM4E (0.38) | KDM4EPKMLMNAKMT2AMEN1 | |
| SCHEMBL29161778 | 0.75 | PDK2 (0.39) | KDM4EPKMLMNAKMT2AALDH1A1 | |
| SCHEMBL11020404 | 0.74 | POLB (0.39) | KDM4EPKMLMNASLC6A2SLC6A4 | |
| SCHEMBL11091963 | 0.74 | GAA (0.44) | KDM4EPKMLMNAKMT2ASMN1; SMN2 | |
| SCHEMBL28886995 | 0.73 | KDM4E (0.41) | KDM4EPKMLMNAKMT2AALDH1A1 | |
| SCHEMBL11489712 | 0.72 | KDM4E (0.49) | KDM4EPKMLMNAKMT2AALDH1A1 | |
| SCHEMBL15691586 | 0.72 | PDK2 (0.50) | KDM4EPKMLMNAKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0018076-B1 | 9-AMINOALKYLFLUORENES, PROCESS THEREFOR AND ANTIARRHYTHMIC FORMULATIONS THEREOF | ELI LILLY AND COMPANY (US) | 1983-09-21 | — | — | EP | disclosed |
| EP-0018076-A1 | 9-Aminoalkylfluorenes, process therefor and antiarrhythmic formulations thereof | ELI LILLY AND COMPANY (US) | 1980-10-29 | — | — | EP | disclosed |
| US-4197313-A | USE OF 9-AMINOALKYL-9-(HYDROXY, CYANO OR CARBAMOYL)-FLUORENES | ELI LILLY AND COMPANY (US) | 1980-04-08 | — | — | US | disclosed |