Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 15/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 15/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.41 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11237110 | 0.85 | GRIN1 (0.57) | GRIN1GRIN2B | |
| SCHEMBL11237761 | 0.84 | PDE3B (0.43) | GRIN1GRIN2BPDE3BPDE3APIK3CD | |
| SCHEMBL11244626 | 0.80 | PDE3B (0.49) | GRIN1GRIN2BPDE3BPDE3APIK3CD | |
| SCHEMBL11227373 | 0.72 | GRIN1 (0.57) | GRIN1GRIN2B | |
| SCHEMBL11236623 | 0.71 | GRIN1 (0.55) | GRIN1GRIN2B | |
| SCHEMBL11244916 | 0.71 | GRIN1 (0.61) | GRIN1GRIN2B | |
| SCHEMBL11363416 | 0.70 | KMT2A (0.46) | CDC7PKN1PKN2AAK1 | |
| SCHEMBL11230943 | 0.70 | GRIN1 (0.55) | GRIN1GRIN2B | |
| SCHEMBL11166310 | 0.69 | PDE3B (0.47) | GRIN1GRIN2BCDC7PKN1PKN2 | |
| SCHEMBL11233554 | 0.69 | GRIN1 (0.53) | GRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4309537-A | Production of imidazo[4,5-b]pyridin-2-ones or thiones | STERLING DRUG INC. (US) | 1982-01-05 | — | — | US | disclosed |
| US-4294837-A | 1,3-Dihydro-6-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones and -imidazo[4,5-b]pyridine-2-thiones and their cardiotonic use | STERLING DRUG INC. (US) | 1981-10-13 | — | — | US | disclosed |