Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 4/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.47 |
| ▸ | CDC7 | O00311 | 1/20 | 0.44 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.44 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 7/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 7/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | FLT4 | P35916 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11353285 | 0.97 | PDE3B (0.45) | PDE3BPDE3ACDC7PKN1PKN2 | |
| Hydrochloric Acid SCHEMBL11237795 | 0.97 | PDE3B (0.45) | PDE3BPDE3ACDC7PKN1PKN2 | |
| SCHEMBL11154216 | 0.93 | ALDH1A1 (0.46) | PDE3BPDE3ACDC7PKN1PKN2 | |
| SCHEMBL11159832 | 0.91 | PDE3B (0.44) | PDE3BPDE3ACDC7PKN1PKN2 | |
| SCHEMBL11157645 | 0.84 | PDE3B (0.49) | PDE3BPDE3ACDC7PKN1PKN2 | |
| SCHEMBL11233977 | 0.84 | ALDH1A1 (0.45) | PDE3BPDE3APDE4BMEN1LMNA | |
| SCHEMBL11157976 | 0.84 | ALDH1A1 (0.50) | PDE3BPDE3APDE4BMEN1LMNA | |
| SCHEMBL11158984 | 0.84 | PDE3B (0.44) | PDE3BPDE3ACDC7PDE4BMEN1 | |
| SCHEMBL11243737 | 0.83 | PDE3B (0.43) | PDE3BPDE3APDE4BMEN1LMNA | |
| SCHEMBL11158720 | 0.82 | LMNA (0.59) | PDE3BPDE3APDE4BMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4294837-A | 1,3-Dihydro-6-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones and -imidazo[4,5-b]pyridine-2-thiones and their cardiotonic use | STERLING DRUG INC. (US) | 1981-10-13 | — | — | US | claimed |
| US-4374141-A | 2-Substituted amino-5-(pyridinyl)-nicotinamides and their cardiotonic use | STERLING DRUG INC. (US) | 1983-02-15 | — | — | US | disclosed |
| US-4309537-A | Production of imidazo[4,5-b]pyridin-2-ones or thiones | STERLING DRUG INC. (US) | 1982-01-05 | — | — | US | disclosed |
| US-4297360-A | 5-(Pyridinyl)pyridine-2,3-diamines, preparation thereof and their cardiotonic use | STERLING DRUG INC. (US) | 1981-10-27 | — | — | US | disclosed |
| US-4294837-A | 1,3-Dihydro-6-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones and -imidazo[4,5-b]pyridine-2-thiones and their cardiotonic use | STERLING DRUG INC. (US) | 1981-10-13 | — | — | US | disclosed |