SCHEMBL11235776

SCHEMBL11235776

COC(=O)C(C)(C)[Si](C)(Cl)Cl

nearest known ligand 0.39

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
DGAT1 O75907 1/20 0.39
KCNN4 O15554 1/20 0.31
ALDH1A1 P00352 1/20 0.30
CYP2C19 P33261 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29095033 0.79 DGAT1 (0.42) DGAT1KCNN4ALDH1A1CYP2C19
SCHEMBL4085493 0.70 DGAT1 (0.39) DGAT1KCNN4ALDH1A1CYP2C19
SCHEMBL7019538 0.69
SCHEMBL6065154 0.67
SCHEMBL4305478 0.67 DGAT1 (0.46) DGAT1KCNN4ALDH1A1
SCHEMBL677960 0.67
SCHEMBL28491585 0.67
SCHEMBL808799 0.66 DGAT1 (0.74) DGAT1KCNN4ALDH1A1CYP2C19
SCHEMBL1424791 0.66 DGAT1 (0.50) DGAT1KCNN4ALDH1A1CYP2C19
SCHEMBL4328011 0.66

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4329483-A FROM A CHLOROSILANE AND ACYLOXY COMPOUND; BY-PRODUCT INHIBITION DOW CORNING CORPORATION (US) 1982-05-11 US disclosed