Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 8/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | TLR4 | O00206 | 1/20 | 0.44 |
| ▸ | TLR2 | O60603 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | F12 | P00748 | 1/20 | 0.42 |
| ▸ | INPPL1 | O15357 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL710165 | 0.81 | CRHBP (0.53) | CHEK2MAPTMEN1KMT2AINPPL1 | |
| SCHEMBL8302605 | 0.81 | MAPT (0.62) | MAPTNPC1RAB9ATLR4TLR2 | |
| SCHEMBL30334403 | 0.79 | MAPT (0.46) | MAPTNPC1RAB9ATLR4TLR2 | |
| SCHEMBL13736898 | 0.78 | MAPT (0.49) | MAPTNPC1RAB9ATLR4TLR2 | |
| SCHEMBL11224806 | 0.77 | INPPL1 (0.49) | CHEK2MAPTMEN1KMT2AINPPL1 | |
| SCHEMBL5036431 | 0.77 | CHEK2 (0.50) | CHEK2RAB9AMEN1CYP2A6INPPL1 | |
| SCHEMBL11168501 | 0.76 | CHEK2 (0.55) | CHEK2MAPTNPC1RAB9ACYP2A6 | |
| SCHEMBL3031212 | 0.75 | MAPT (0.63) | MAPTNPC1RAB9ATLR4TLR2 | |
| SCHEMBL6503392 | 0.75 | MAPT (0.49) | MAPTNPC1RAB9ATLR4TLR2 | |
| SCHEMBL6974757 | 0.75 | AURKB (0.50) | MAPTNPC1RAB9ATLR4TLR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4309537-A | Production of imidazo[4,5-b]pyridin-2-ones or thiones | STERLING DRUG INC. (US) | 1982-01-05 | — | — | US | disclosed |
| US-4297360-A | 5-(Pyridinyl)pyridine-2,3-diamines, preparation thereof and their cardiotonic use | STERLING DRUG INC. (US) | 1981-10-27 | — | — | US | disclosed |
| US-4294837-A | 1,3-Dihydro-6-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones and -imidazo[4,5-b]pyridine-2-thiones and their cardiotonic use | STERLING DRUG INC. (US) | 1981-10-13 | — | — | US | disclosed |
| US-4276293-A | Compositions and their preparation | STERLING DRUG INC. (US) | 1981-06-30 | — | — | US | disclosed |