Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 4/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.42 |
| ▸ | LATS1 | O95835 | 1/20 | 0.39 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.39 |
| ▸ | PGK1 | P00558 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.35 |
| ▸ | CASP1 | P29466 | 3/20 | 0.35 |
| ▸ | CASP7 | P55210 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | AHR | P35869 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11223425 | 0.86 | PDE3B (0.46) | PDE3BPDE3ALATS1LATS2PGK1 | |
| SCHEMBL11229128 | 0.84 | KDM4E (0.50) | PDE3BPDE3AKDM4EHSD17B10CASP1 | |
| SCHEMBL11238221 | 0.81 | PDE3B (0.41) | PDE3BPDE3AKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL11238631 | 0.78 | PDE3B (0.39) | PDE3BPDE3ALATS1LATS2KDM4E | |
| SCHEMBL11229759 | 0.76 | GSK3B (0.46) | PDE3BPDE3ALATS1LATS2PGK1 | |
| SCHEMBL11227748 | 0.74 | MAPT (0.39) | PDE3BPDE3AKDM4EHSD17B10MAPT | |
| SCHEMBL11246839 | 0.71 | GSK3B (0.38) | PDE3BPDE3AKDM4EHSD17B10MAPT | |
| SCHEMBL11384185 | 0.70 | PDE3B (0.49) | PDE3BPDE3AKDM4EHPGDAAK1 | |
| SCHEMBL11245015 | 0.70 | PDE3B (0.39) | PDE3BPDE3AKDM4EHSD17B10CASP1 | |
| SCHEMBL11238606 | 0.70 | GSK3B (0.37) | KDM4EHSD17B10MAPTALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4361568-A | 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridin-3-amines and their cardiotonic use | STERLING DRUG INC. (US) | 1982-11-30 | — | — | US | disclosed |
| EP-0063754-A1 | Pyrazolopyridine derivatives, and preparation, useful as cardiotonics | STERLING DRUG INC. (US) | 1982-11-03 | — | — | EP | disclosed |