Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | CDC7 | O00311 | 2/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11238606 | 0.96 | GSK3B (0.37) | GSK3BCYP17A1TLR7MAPTTSHR | |
| SCHEMBL11227748 | 0.94 | MAPT (0.39) | GSK3BCYP17A1MAPTTSHRTDP1 | |
| SCHEMBL11238221 | 0.89 | PDE3B (0.41) | GSK3BCYP17A1ALDH1A1JAK2MAPK1 | |
| SCHEMBL11232990 | 0.79 | PDE3B (0.51) | GSK3BALDH1A1JAK2MAPK1HSD17B10 | |
| SCHEMBL11177593 | 0.77 | GSK3B (0.36) | GSK3BCYP17A1TLR7MAPTTSHR | |
| SCHEMBL11245015 | 0.75 | PDE3B (0.39) | CYP17A1ALDH1A1JAK2MAPK1HSD17B10 | |
| SCHEMBL11385500 | 0.75 | GSK3B (0.43) | GSK3BTSHRALDH1A1NPSR1HSD17B10 | |
| SCHEMBL2932326 | 0.73 | MAPK14 (0.51) | AKT1AKT2 | |
| SCHEMBL11377563 | 0.71 | GSK3B (0.39) | GSK3BTSHRALDH1A1NPSR1HSD17B10 | |
| SCHEMBL11235962 | 0.71 | PDE3B (0.42) | MAPTALDH1A1MAPK1HSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4361568-A | 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridin-3-amines and their cardiotonic use | STERLING DRUG INC. (US) | 1982-11-30 | — | — | US | disclosed |
| US-4264603-A | 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridine-3-amines, their use as cardiotonics and their preparation | STERLING DRUG INC. (US) | 1981-04-28 | — | — | US | disclosed |