Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | AKT2 | P31751 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 3/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | HCK | P08631 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.34 |
| ▸ | PRKDC | P78527 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11231193 | 0.89 | MAPK1 (0.39) | MAPK1AKT1AKT2KDM4EHSD17B10 | |
| SCHEMBL11238864 | 0.87 | AAK1 (0.36) | PDE3BPDE3AMAPK1AKT1AKT2 | |
| SCHEMBL11240784 | 0.85 | PDE3B (0.46) | PDE3BPDE3AMAPK1AKT1AKT2 | |
| SCHEMBL11238221 | 0.85 | PDE3B (0.41) | PDE3BPDE3AMAPK1AKT1AKT2 | |
| SCHEMBL11227748 | 0.76 | MAPT (0.39) | PDE3BPDE3AMAPK1AKT1AKT2 | |
| SCHEMBL11238805 | 0.75 | MTOR (0.40) | PIK3CDPIK3CAPIK3CBMTORPRKDC | |
| SCHEMBL11244896 | 0.75 | GSK3B (0.49) | MAPK1AKT1EGFRKDRPIK3CA | |
| SCHEMBL11246839 | 0.75 | GSK3B (0.38) | PDE3BPDE3AMAPK1AKT1AKT2 | |
| SCHEMBL11238606 | 0.74 | GSK3B (0.37) | MAPK1KDM4EHSD17B10ROCK2CYP17A1 | |
| SCHEMBL11173371 | 0.71 | PDE3B (0.42) | PDE3BPDE3AMAPK1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4361568-A | 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridin-3-amines and their cardiotonic use | STERLING DRUG INC. (US) | 1982-11-30 | — | — | US | disclosed |
| US-4264603-A | 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridine-3-amines, their use as cardiotonics and their preparation | STERLING DRUG INC. (US) | 1981-04-28 | — | — | US | disclosed |