Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SI | P14410 | 1/20 | 0.35 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL351718 | 0.76 | ALDH1A1 (0.48) | ALDH1A1HSD17B10LMNAFAAHSMN1; SMN2 | |
| SCHEMBL4642316 | 0.76 | ALDH1A1 (0.48) | ALDH1A1HSD17B10LMNAFAAHSMN1; SMN2 | |
| SCHEMBL3941105 | 0.76 | — | — | |
| Ethyl Acetate SCHEMBL28441620 | 0.75 | ALDH1A1 (0.61) | ALDH1A1HSD17B10LMNASMN1; SMN2MGAM | |
| SCHEMBL10986742 | 0.74 | ALDH1A1 (0.46) | ALDH1A1HSD17B10LMNAFAAHSMN1; SMN2 | |
| SCHEMBL2607864 | 0.74 | — | — | |
| SCHEMBL28238199 | 0.74 | ALDH1A1 (0.46) | ALDH1A1HSD17B10LMNAFAAHSMN1; SMN2 | |
| SCHEMBL4645361 | 0.72 | ALDH1A1 (0.43) | ALDH1A1HSD17B10LMNAFAAHSMN1; SMN2 | |
| SCHEMBL4642312 | 0.72 | ALDH1A1 (0.43) | ALDH1A1HSD17B10LMNAFAAHSMN1; SMN2 | |
| SCHEMBL9311644 | 0.72 | ALDH1A1 (0.43) | ALDH1A1HSD17B10LMNAFAAHSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0000383-B1 | PYRIMIDO (4,5-C) PYRIDAZINES, THEIR USE IN PHARMACEUTICAL PREPARATIONS, AND PROCESS FOR THEIR PREPARATION | THE WELLCOME FOUNDATION LIMITED (GB) | 1982-10-13 | — | — | EP | disclosed |
| EP-0000382-B1 | PYRIMIDO (4,5-C)PYRIDAZINES, COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION | THE WELLCOME FOUNDATION LIMITED (GB) | 1982-10-06 | — | — | EP | disclosed |
| US-4329362-A | INHIBITORS OF DIHYDROPTEROIC AND BIOSYNTHESES | BURROUGHS WELLCOME CO. (US) | 1982-05-11 | — | — | US | disclosed |
| US-4323679-A | CHEMICAL INTERMEDIATES | BURROUGHS WELLCOME CO. (US) | 1982-04-06 | — | — | US | disclosed |
| US-4303789-A | INHIBITORS OF DIHYDROPTERIC ACID AND BIOSYNTHESIS | BURROUGHS WELLCOME CO. (US) | 1981-12-01 | — | — | US | disclosed |
| US-4303790-A | INHIBITORS OF DIHYDROPTERIC ACID AND BIOSYNTHESIS | BURROUGHS WELLCOME CO. (US) | 1981-12-01 | — | — | US | disclosed |
| US-4302587-A | INTERMEDIATE FOR ENZYME INHIBITING PYRIMIDO(4,5-C)PYRIDAZINES | BURROUGHS WELLCOME CO. (US) | 1981-11-24 | — | — | US | disclosed |
| US-4255427-A | TREATMENT OF COCCIDIOSIS IN POULTRY | BURROUGHS WELLCOME CO. (US) | 1981-03-10 | — | — | US | disclosed |
| US-4225710-A | ENZYME INHIBITORS | BURROUGHS WELLCOME CO. (US) | 1980-09-30 | — | — | US | disclosed |
| EP-0000382-A1 | Pyrimido (4,5-c)pyridazines, compositions containing them and processes for their preparation | THE WELLCOME FOUNDATION LIMITED (GB) | 1979-01-24 | — | — | EP | disclosed |
| EP-0000383-A1 | Pyrimido (4,5-c) pyridazines, their use in pharmaceutical preparations, and process for their preparation | THE WELLCOME FOUNDATION LIMITED (GB) | 1979-01-24 | — | — | EP | disclosed |