SCHEMBL351718

SCHEMBL351718

C=C(COC(C)=O)C(=O)OC

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.48
HSD17B10 Q99714 3/20 0.39
LMNA P02545 1/20 0.39
FAAH O00519 1/20 0.36
TSHR P16473 2/20 0.34
SMN1; SMN2 Q16637 5/20 0.34
TDP1 Q9NUW8 1/20 0.33
THRB P10828 1/20 0.32
PGR P06401 1/20 0.32
CHRM2 P08172 1/20 0.32
CHRM4 P08173 1/20 0.32
HTR1A P08908 1/20 0.32
CHRM5 P08912 1/20 0.32
CHRM1 P11229 1/20 0.32
CHRNB2 P17787 1/20 0.32
CHRM3 P20309 1/20 0.32
TBXA2R P21731 1/20 0.32
CHRNB4 P30926 1/20 0.32
CHRNA3 P32297 1/20 0.32
CHRNA7 P36544 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28286108 0.82 HSD17B10 (0.44) ALDH1A1HSD17B10LMNAFAAHTSHR
SCHEMBL2258666 0.80 ALDH1A1 (0.54) ALDH1A1HSD17B10LMNAFAAHTSHR
SCHEMBL15926084 0.80 ALDH1A1 (0.41) ALDH1A1HSD17B10LMNATSHRCHRM2
SCHEMBL27990481 0.78 ALDH1A1 (0.44) ALDH1A1HSD17B10LMNATSHRSMN1; SMN2
SCHEMBL11446032 0.78 ALDH1A1 (0.43) ALDH1A1HSD17B10LMNAFAAHTSHR
SCHEMBL352782 0.78
SCHEMBL353002 0.78 ALDH1A1 (0.48) ALDH1A1HSD17B10TSHRTHRBMGAM
SCHEMBL28840951 0.77 TSHR (0.44) ALDH1A1HSD17B10TSHRSMN1; SMN2THRB
SCHEMBL352638 0.77 ALDH1A1 (0.34) ALDH1A1HSD17B10LMNAFAAHTSHR
SCHEMBL6659743 0.77 TSHR (0.44) ALDH1A1HSD17B10LMNAFAAHTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116426103-A Polylactic acid-based environment-friendly degradable material and preparation method thereof 江西省隆旭科技有限公司 2023-07-14 CN claimed
US-20250188023-A1 BENZENE DERIVATIVE ONO PHARMACEUTICAL CO., LTD. (JP) 2025-06-12 US disclosed
US-12258308-B2 Benzene derivative ONO PHARMACEUTICAL CO., LTD. (JP) 2025-03-25 US disclosed
CN-116426103-A Polylactic acid-based environment-friendly degradable material and preparation method thereof 江西省隆旭科技有限公司 2023-07-14 CN disclosed
CN-112513011-B Benzene derivatives 小野药品工业株式会社 2023-06-16 CN disclosed
US-20220089532-A1 BENZENE DERIVATIVE ONO PHARMACEUTICAL CO., LTD. (JP) 2022-03-24 US disclosed
US-11261154-B2 Benzene derivative ONO PHARMACEUTICAL CO., LTD. (JP) 2022-03-01 US disclosed
US-20210380635-A1 COMPOSITIONS AND METHODS FOR PROTEIN LABELING, MODIFICATION, ANALYSIS, AND TARGETED DELIVERY NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2021-12-09 US disclosed
US-20210332009-A1 BENZENE DERIVATIVE ONO PHARMACEUTICAL CO., LTD. (JP) 2021-10-28 US disclosed
EP-3831810-A1 BENZENE DERIVATIVE ONO Pharmaceutical Co., Ltd. (JP) 2021-06-09 EP disclosed
US-20120016095-A1 a-(UNSATURATED ALKOXYALKYL) ACRYLATE COMPOSITION AND PROCESS FOR PRODUCTION THEREOF NIPPON SHOKUBAI CO., LTD. (JP) 2012-01-19 US disclosed
CN-101768125-A Triazole compound and preparation method thereof UNIV ZHEJIANG 2010-07-07 CN disclosed
US-20100076217-A1 ACYLOXYLATION CATALYST AND PROCESS FOR ITS PRODUCTION SHOWA DENKO K.K. (JP) 2010-03-25 US disclosed
EP-2099563-A1 ACYLOXYLATION CATALYST AND PROCESS FOR ITS PRODUCTION Showa Denko K.K. (JP) 2009-09-16 EP disclosed
WO-2008075588-A1 ACYLOXYLATION CATALYST AND PROCESS FOR ITS PRODUCTION SHOWA DENKO K.K. (JP) 2008-06-26 WO disclosed
WO-2007070398-A1 POLYCYCLIC INDAZOLE DERIVATIVES THAT ARE ERK INHIBITORS SCHERING CORPORATION (US) 2007-06-21 WO disclosed
EP-1123915-B1 Process for producing alpha, beta-unsaturated carboxylic acid esters and catalyst for use in such process NIPPON CATALYTIC CHEM IND (JP) 2004-07-28 EP disclosed
US-6541656-B2 Reacting an alpha, beta unsaturated carboxylic acid ester with a heterocyclic oxygen nitrogen, or sulfur compound NIPPON SHOKUBAI COMPANY, LTD. (JP) 2003-04-01 US disclosed
US-20010034300-A1 Reacting an alpha, beta unsaturated carboxylic acid ester with a heterocyclic oxygen nitrogen, or sulfur compound NIPPON SHOKUBAI COMPANY LTD. (JP) 2001-10-25 US disclosed
EP-1123915-A1 Process for producing alpha, beta-unsaturated carboxylic acid esters and catalyst for use in such process Nippon Shokubai Co., Ltd. (JP) 2001-08-16 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12258308-B2 Benzene derivative PMP22, TMBIM6, MYT1 ALDH1A1 1189/4885HSD17B10 3696/4885LMNA 1367/4885
US-11261154-B2 Benzene derivative PMP22, TMBIM6, MYT1 ALDH1A1 1189/4885HSD17B10 3696/4885LMNA 1367/4885
US-20250188023-A1 BENZENE DERIVATIVE PMP22, TMBIM6, MYT1 ALDH1A1 1203/4885HSD17B10 3766/4885LMNA 1430/4885
US-20210380635-A1 COMPOSITIONS AND METHODS FOR PROTEIN LABELING, MODIFICATION, ANALYSIS, AND TARGETED DELIVERY PTMS, SRMS, CHAMP1 ALDH1A1 3049/4885HSD17B10 4088/4885LMNA 2586/4885
US-20210332009-A1 BENZENE DERIVATIVE PMP22, TMBIM6, MYT1 ALDH1A1 1189/4885HSD17B10 3696/4885LMNA 1367/4885
US-20220089532-A1 BENZENE DERIVATIVE PMP22, TMBIM6, MYT1 ALDH1A1 1189/4885HSD17B10 3696/4885LMNA 1367/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.