Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | LATS1 | O95835 | 2/20 | 0.45 |
| ▸ | LATS2 | Q9NRM7 | 2/20 | 0.45 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11237675 | 0.87 | PRKCD (0.46) | POLBTP53L3MBTL1LMNAMAPT | |
| SCHEMBL11237964 | 0.86 | GBA1 (0.48) | POLBTP53L3MBTL1HCAR3LMNA | |
| SCHEMBL11227394 | 0.86 | GAA (0.49) | POLBTP53LATS1LATS2HCAR3 | |
| SCHEMBL11230984 | 0.86 | POLB (0.47) | POLBTP53L3MBTL1LMNAMAPT | |
| SCHEMBL11236111 | 0.86 | SMN1; SMN2 (0.45) | POLBTP53L3MBTL1LMNAMAPT | |
| SCHEMBL11238534 | 0.84 | ROCK2 (0.44) | POLBTP53LATS1LATS2LMNA | |
| SCHEMBL11231160 | 0.84 | POLB (0.39) | POLBTP53L3MBTL1LMNAMAPT | |
| SCHEMBL11236993 | 0.83 | ALDH1A1 (0.45) | POLBTP53MAPTALDH1A1GAA | |
| SCHEMBL11227665 | 0.81 | MAPT (0.50) | POLBTP53L3MBTL1HCAR3LMNA | |
| SCHEMBL22904063 | 0.80 | POLB (0.67) | POLBTP53HCAR3LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4309537-A | Production of imidazo[4,5-b]pyridin-2-ones or thiones | STERLING DRUG INC. (US) | 1982-01-05 | — | — | US | disclosed |
| US-4297360-A | 5-(Pyridinyl)pyridine-2,3-diamines, preparation thereof and their cardiotonic use | STERLING DRUG INC. (US) | 1981-10-27 | — | — | US | disclosed |
| US-4294837-A | 1,3-Dihydro-6-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones and -imidazo[4,5-b]pyridine-2-thiones and their cardiotonic use | STERLING DRUG INC. (US) | 1981-10-13 | — | — | US | disclosed |
| US-4276293-A | Compositions and their preparation | STERLING DRUG INC. (US) | 1981-06-30 | — | — | US | disclosed |