Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | ESRRA | P11474 | 1/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11255920 | 0.89 | L3MBTL1 (0.80) | L3MBTL1KMT2AMEN1GAAKDM4E | |
| SCHEMBL11240303 | 0.85 | L3MBTL1 (0.74) | L3MBTL1KMT2AMEN1GAAKDM4E | |
| SCHEMBL11268300 | 0.84 | L3MBTL1 (0.72) | L3MBTL1KMT2AMEN1GAAKDM4E | |
| SCHEMBL11250852 | 0.82 | L3MBTL1 (0.70) | L3MBTL1KMT2AMEN1GAAKDM4E | |
| SCHEMBL11246293 | 0.82 | L3MBTL1 (0.69) | L3MBTL1KMT2AMEN1GAAESRRA | |
| SCHEMBL11237480 | 0.81 | L3MBTL1 (0.68) | L3MBTL1KMT2AMEN1GAAKDM4E | |
| SCHEMBL11245813 | 0.81 | L3MBTL1 (0.68) | L3MBTL1KMT2AMEN1GAAKDM4E | |
| SCHEMBL11254345 | 0.81 | L3MBTL1 (0.68) | L3MBTL1KMT2AMEN1GAAESRRA | |
| SCHEMBL11248370 | 0.80 | L3MBTL1 (0.67) | L3MBTL1KMT2AMEN1GAAKDM4E | |
| SCHEMBL11252191 | 0.80 | L3MBTL1 (0.67) | L3MBTL1KMT2AMEN1GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170267648-A1 | SUBSTITUTED URACILS AS CHYMASE INHIBITORS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-09-21 | — | — | US | disclosed |
| US-9695131-B2 | Substituted uracils as chymase inhibitors | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-07-04 | — | — | US | disclosed |
| US-20160244415-A1 | SUBSTITUTED URACILS AS CHYMASE INHIBITORS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-08-25 | — | — | US | disclosed |
| CN-105873919-A | Substituted uracils as chymase inhibitors | 拜耳医药股份有限公司 | 2016-08-17 | — | — | CN | disclosed |
| US-4358591-A | BACTERICIDES, FUNGICIDES; PLANT DISEASES | ZOECON CORPORATION (US) | 1982-11-09 | — | — | US | disclosed |
| US-4338318-A | FUNGICIDE OR BACERICIDE TO TREAT PLANT DISEASES WITH A PHENYL URACIL | ZOECON CORPORATION (US) | 1982-07-06 | — | — | US | disclosed |
| US-4307098-A | 2-PHENYL-URACIL COMPOUNDS | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1981-12-22 | — | — | US | disclosed |
| US-4297297-A | α-Cyano-β-(substituted-anilino)-N-ethoxycarbonylacrylamide intermediates | ZOECON CORP. (US) | 1981-10-27 | — | — | US | disclosed |
| US-4266056-A | FUNGICIDES, BACTERICIDES | ZOECON CORPORATION (US) | 1981-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170267648-A1 | SUBSTITUTED URACILS AS CHYMASE INHIBITORS | CMA1, UNG, TYMP | L3MBTL1 785/4885KMT2A 3644/4885MEN1 2730/4885 |
| US-20160244415-A1 | SUBSTITUTED URACILS AS CHYMASE INHIBITORS | UNG, CMA1, TYMP | L3MBTL1 2468/4885KMT2A 3293/4885MEN1 1807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.