Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11237627 | 1.00 | POLB (0.49) | POLBTDP1THRBRECQLL3MBTL1 | |
| SCHEMBL11237581 | 0.78 | TSHR (0.53) | POLBTDP1THRBRECQLL3MBTL1 | |
| SCHEMBL11237579 | 0.78 | TSHR (0.53) | POLBTDP1THRBRECQLL3MBTL1 | |
| SCHEMBL8065539 | 0.76 | SMN1; SMN2 (0.71) | POLBTDP1THRBRECQLL3MBTL1 | |
| SCHEMBL11243738 | 0.76 | TSHR (0.55) | POLBTDP1THRBRECQLL3MBTL1 | |
| SCHEMBL11243743 | 0.76 | TSHR (0.55) | POLBTDP1THRBRECQLL3MBTL1 | |
| SCHEMBL1144066 | 0.75 | ALDH1A1 (0.69) | POLBTDP1THRBRECQLL3MBTL1 | |
| SCHEMBL29712843 | 0.75 | ALDH1A1 (0.69) | POLBTDP1THRBRECQLL3MBTL1 | |
| SCHEMBL11239698 | 0.75 | MAPT (0.50) | POLBTDP1THRBRECQLL3MBTL1 | |
| SCHEMBL11239695 | 0.75 | MAPT (0.50) | POLBTDP1THRBRECQLL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4317831-A | Antimicrobial derivatives of 3-(1H-imidazol-1-yl)-2-propen-1-ones | E. R. SQUIBB & SONS, INC. (US) | 1982-03-02 | — | — | US | disclosed |
| US-4273776-A | Antibacterial and antifungal derivatives of 3-(1H-imidazol-1-yl)-2-propen-1-ones | E. R. SQUIBB & SONS, INC. (US) | 1981-06-16 | — | — | US | disclosed |