Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.61 |
| ▸ | METAP1 | P53582 | 3/20 | 0.51 |
| ▸ | CYP24A1 | Q07973 | 6/20 | 0.49 |
| ▸ | CYP27A1 | Q02318 | 3/20 | 0.49 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.43 |
| ▸ | NQO2 | P16083 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10341545 | 0.90 | CYP24A1 (0.61) | CYP19A1METAP1CYP24A1CYP27A1CYP26A1 | |
| SCHEMBL11011369 | 0.81 | METAP1 (0.76) | CYP19A1METAP1CYP24A1CYP27A1CYP26A1 | |
| SCHEMBL11239357 | 0.81 | ACHE (0.47) | ACHE | |
| SCHEMBL9629597 | 0.81 | MTNR1A (0.56) | MTNR1ANQO2MTNR1B | |
| SCHEMBL31028061 | 0.81 | MTNR1A (0.56) | MTNR1ANQO2MTNR1B | |
| Hydrochloric Acid SCHEMBL4623159 | 0.80 | METAP1 (0.78) | CYP19A1METAP1CYP24A1CYP27A1CYP26A1 | |
| SCHEMBL8599809 | 0.80 | CYP19A1 (0.62) | CYP19A1METAP1CYP24A1CYP27A1CYP26A1 | |
| SCHEMBL8028175 | 0.79 | CYP19A1 (0.61) | CYP19A1METAP1CYP24A1CYP27A1CYP26A1 | |
| SCHEMBL9430945 | 0.79 | CYP19A1 (0.61) | CYP19A1METAP1CYP24A1CYP27A1CYP26A1 | |
| Iodide SCHEMBL9133365 | 0.79 | CYP19A1 (0.61) | CYP19A1METAP1CYP24A1CYP27A1CYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4309345-A | POTASSIUM-SPARING DIURETICS | CIBA-GEIGY CORPORATION (US) | 1982-01-05 | — | — | US | disclosed |
| US-4173633-A | DIURETICS | CIBA-GEIGY CORPORATION (US) | 1979-11-06 | — | — | US | disclosed |