Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 9/20 | 0.53 |
| ▸ | ADRB3 | P13945 | 8/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 8/20 | 0.53 |
| ▸ | DRD4 | P21917 | 6/20 | 0.52 |
| ▸ | DRD2 | P14416 | 5/20 | 0.51 |
| ▸ | DRD3 | P35462 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11234691 | 0.99 | ADRB2 (0.52) | ADRB2ADRB3ADRB1DRD4DRD2 | |
| SCHEMBL11377069 | 0.93 | ADRB3 (0.53) | ADRB2ADRB3ADRB1DRD4DRD2 | |
| SCHEMBL11372455 | 0.90 | GAA (0.49) | ADRB2ADRB3ADRB1MEN1CYP1A2 | |
| Hydrochloric Acid SCHEMBL11374081 | 0.89 | KMT2A (0.50) | ADRB2ADRB3ADRB1MEN1CYP1A2 | |
| Hydrochloric Acid SCHEMBL11371219 | 0.88 | ADRB3 (0.54) | ADRB2ADRB3ADRB1DRD4MEN1 | |
| Hydrochloric Acid SCHEMBL11245484 | 0.86 | ADRB3 (0.67) | ADRB2ADRB3ADRB1DRD4DRD2 | |
| Hydrochloric Acid SCHEMBL11467590 | 0.85 | KMT2A (0.52) | DRD4DRD2DRD3MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL11372638 | 0.83 | ADRB2 (0.43) | ADRB2ADRB3ADRB1DRD4MEN1 | |
| Mindodilol SCHEMBL2107921 | 0.83 | ADRB2 (0.63) | ADRB2ADRB3ADRB1DRD4DRD2 | |
| Mindodilol SCHEMBL11540170 | 0.83 | ADRB2 (0.63) | ADRB2ADRB3ADRB1DRD4DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0014928-B1 | PIPERIDINOPROPYL DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE COMPOUNDS | Roche Diagnostics GmbH (DE) | 1982-05-05 | — | — | EP | disclosed |
| US-4288442-A | Inhibiting adrenergic β-receptors with piperidinopropyl derivatives | BOEHRINGER MANNHEIM GMBH (DE) | 1981-09-08 | — | — | US | disclosed |