Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.63 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.63 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.63 |
| ▸ | HTR1A | P08908 | 18/20 | 0.62 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.62 |
| ▸ | DRD2 | P14416 | 1/20 | 0.57 |
| ▸ | DRD4 | P21917 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mindodilol SCHEMBL11540170 | 1.00 | ADRB2 (0.63) | ADRB2ADRB1ADRB3HTR1ASLC6A4 | |
| Mindodilol SCHEMBL6295415 | 0.95 | ADRB2 (0.61) | ADRB2ADRB1ADRB3HTR1ASLC6A4 | |
| SCHEMBL11541170 | 0.89 | HTR1A (0.64) | ADRB2ADRB1ADRB3HTR1ASLC6A4 | |
| SCHEMBL11541941 | 0.89 | ADRB2 (0.59) | ADRB2ADRB1ADRB3HTR1ASLC6A4 | |
| SCHEMBL11539522 | 0.89 | HTR1A (0.66) | ADRB2ADRB1ADRB3HTR1ASLC6A4 | |
| SCHEMBL7876327 | 0.88 | DRD2 (0.74) | ADRB2ADRB1ADRB3HTR1ASLC6A4 | |
| SCHEMBL11540486 | 0.88 | ADRB2 (0.61) | ADRB2ADRB1ADRB3HTR1ASLC6A4 | |
| Benzoic Acid SCHEMBL11544384 | 0.88 | HTR1A (0.57) | ADRB2ADRB1ADRB3HTR1ASLC6A4 | |
| SCHEMBL7885674 | 0.87 | DRD4 (0.73) | ADRB2ADRB1ADRB3HTR1ASLC6A4 | |
| SCHEMBL11537570 | 0.86 | DRD4 (0.52) | ADRB2ADRB1ADRB3HTR1ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 121 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9016221-B2 | Surface topographies for non-toxic bioadhesion control | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2015-04-28 | — | — | US | claimed |
| US-20100226943-A1 | SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL | UNIVERSITY OF FLORIDA (US) | 2010-09-09 | — | — | US | claimed |
| CN-101330905-A | Freeze-drying process and products obtained thereby | SCIDOSE LLC (US) | 2008-12-24 | — | — | CN | claimed |
| EP-1954244-A1 | LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY | Scidose, Llc (US) | 2008-08-13 | — | — | EP | claimed |
| WO-2007061529-A1 | LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY | SCIDOSE LLC. (US) | 2007-05-31 | — | — | WO | claimed |
| US-20070116729-A1 | Lyophilization process and products obtained thereby | SCIDOSE LLC | 2007-05-24 | — | — | US | claimed |
| US-6852337-B2 | Carvedilol-galenics | ROCHE DIAGNOSTICS GMBH (DE) | 2005-02-08 | — | — | US | claimed |
| EP-1069896-B1 | CARVEDILOL-GALENICS | ROCHE DIAGNOSTICS GMBH (DE) | 2003-08-06 | — | — | EP | claimed |
| US-20030118643-A1 | Carvedilol-galenics | GABEL ROLF-DIETER (DE) | 2003-06-26 | — | — | US | claimed |
| EP-1069896-A1 | CARVEDILOL-GALENICS | Roche Diagnostics GmbH (DE) | 2001-01-24 | — | — | EP | claimed |
| US-4782043-A | HYPOTENSIVES | MERCK & CO., INC. (US) | 1988-11-01 | — | — | US | claimed |
| EP-0278158-A2 | Renin inhibitors containing phenylalanyl-histidine replacements | MERCK & CO. INC. (US) | 1988-08-17 | — | — | EP | claimed |
| EP-0273696-A2 | Renin inhibitors containing histidine replacements | MERCK & CO. INC. (US) | 1988-07-06 | — | — | EP | claimed |
| EP-0209897-A2 | Peptide enzyme inhibitors | MERCK & CO. INC. (US) | 1987-01-28 | — | — | EP | claimed |
| EP-0163237-A2 | Di- and tri-peptidal renin inhibitors | MERCK & CO. INC. (US) | 1985-12-04 | — | — | EP | claimed |
| EP-0157409-A2 | Renin inhibitors containing 2-substituted statine | MERCK & CO. INC. (US) | 1985-10-09 | — | — | EP | claimed |
| EP-0156318-A2 | C-terminal amide cyclic renin inhibitors containing peptide isosteres | MERCK & CO. INC. (US) | 1985-10-02 | — | — | EP | claimed |
| EP-0156322-A2 | Renin inhibitors containing peptide isosteres | MERCK & CO. INC. (US) | 1985-10-02 | — | — | EP | claimed |
| EP-0129189-A2 | Renin inhibitors containing a C-terminal amide cycle and compositions and combinations containing the same | MERCK & CO. INC. (US) | 1984-12-27 | — | — | EP | claimed |
| US-4146630-A | HYPOTENSIVE AGENTS | BOEHRINGER MANNHEIM GMBH (DE) | 1979-03-27 | — | — | US | claimed |