Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | GSR | P00390 | 2/20 | 0.37 |
| ▸ | TXNRD1 | Q16881 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.34 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL562804 | 0.87 | ALDH1A1 (0.41) | KCNH2ALDH1A1TSHRGSRTXNRD1 | |
| SCHEMBL11798967 | 0.76 | ALDH1A1 (0.44) | ALDH1A1TSHRMAPTNOS2 | |
| SCHEMBL15080227 | 0.75 | MAPT (0.46) | ALDH1A1TSHRMAPT | |
| SCHEMBL10504960 | 0.74 | ALDH1A1 (0.42) | ALDH1A1TSHRMAPT | |
| SCHEMBL18226831 | 0.72 | ALDH1A1 (0.50) | ALDH1A1TSHRMAPT | |
| SCHEMBL30841780 | 0.72 | ALDH1A1 (0.50) | ALDH1A1TSHRMAPT | |
| SCHEMBL29367224 | 0.72 | ALDH1A1 (0.50) | ALDH1A1TSHRMAPT | |
| SCHEMBL1625586 | 0.72 | ALDH1A1 (0.50) | ALDH1A1TSHRMAPT | |
| SCHEMBL563635 | 0.71 | GPR84 (0.39) | KCNH2GPR84 | |
| SCHEMBL7479136 | 0.69 | GSR (0.34) | KCNH2ALDH1A1GSRTXNRD1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0013408-B1 | 4-AMINOPYRIDINES, PROCESS FOR THEIR PREPARATION AND DRUGS CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-05-26 | — | — | EP | disclosed |
| US-4289765-A | BRONCHOSPASMOLYTIC AGENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-09-15 | — | — | US | disclosed |
| EP-0013408-A1 | 4-Aminopyridines, process for their preparation and drugs containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-07-23 | — | — | EP | disclosed |