Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.32 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.32 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.32 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.32 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.32 |
| ▸ | NDUFS8 | O00217 | 1/20 | 0.32 |
| ▸ | COXFA4 | O00483 | 1/20 | 0.32 |
| ▸ | NDUFAB1 | O14561 | 1/20 | 0.32 |
| ▸ | NDUFA1 | O15239 | 1/20 | 0.32 |
| ▸ | NDUFS4 | O43181 | 1/20 | 0.32 |
| ▸ | NDUFB5 | O43674 | 1/20 | 0.32 |
| ▸ | NDUFB3 | O43676 | 1/20 | 0.32 |
| ▸ | NDUFC1 | O43677 | 1/20 | 0.32 |
| ▸ | NDUFA2 | O43678 | 1/20 | 0.32 |
| ▸ | NDUFS5 | O43920 | 1/20 | 0.32 |
| ▸ | NDUFS7 | O75251 | 1/20 | 0.32 |
| ▸ | NDUFS2 | O75306 | 1/20 | 0.32 |
| ▸ | NDUFS6 | O75380 | 1/20 | 0.32 |
| ▸ | NDUFB1 | O75438 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11232289 | 0.99 | NDUFS8 (0.33) | NDUFS8COXFA4NDUFAB1NDUFA1NDUFS4 | |
| SCHEMBL11225526 | 0.97 | NDUFS8 (0.33) | NDUFS8COXFA4NDUFAB1NDUFA1NDUFS4 | |
| Bromide SCHEMBL11137501 | 0.96 | CACNA1B (0.32) | NDUFS8COXFA4NDUFAB1NDUFA1NDUFS4 | |
| SCHEMBL11236299 | 0.95 | CACNA1B (0.33) | NDUFS8COXFA4NDUFAB1NDUFA1NDUFS4 | |
| Bromide SCHEMBL11140930 | 0.76 | MAOB (0.37) | MAOB | |
| Bromide SCHEMBL11147068 | 0.75 | GLA (0.39) | — | |
| SCHEMBL11228647 | 0.75 | MAOB (0.38) | MAOB | |
| SCHEMBL11236572 | 0.74 | GLA (0.40) | — | |
| SCHEMBL11245133 | 0.74 | CA4 (0.31) | — | |
| SCHEMBL11233344 | 0.73 | MAOB (0.39) | MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4336252-A | 1-Cycloalkyl phosphonium salts | G. D. SEARLE & CO. (US) | 1982-06-22 | — | — | US | disclosed |