NDUFS8 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Auraptene (SCHEMBL2535029)	1.00	5/20
Auraptene (SCHEMBL2535034)	1.00	5/20
SCHEMBL8491443	0.56	4/20
SCHEMBL8489900	0.52	4/20
SCHEMBL8489907	0.52	4/20
SCHEMBL8489902	0.51	4/20
SCHEMBL8489908	0.51	4/20
SCHEMBL8491154	0.51	4/20
SCHEMBL8491160	0.51	4/20
SCHEMBL8491619	0.50	4/20
SCHEMBL8491624	0.50	4/20
SCHEMBL8491634	0.50	4/20
7-Prenyloxycoumarin (SCHEMBL4898255)	0.79	3/20
SCHEMBL712741	0.57	3/20
Geiparvarin (SCHEMBL2532495)	0.56	3/20
SCHEMBL6267768	0.55	3/20
SCHEMBL1095981	0.55	3/20
SCHEMBL4293165	0.55	3/20
SCHEMBL8490928	0.53	3/20
SCHEMBL8490937	0.53	3/20

Clinical trials — most relevant to NDUFS8 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Phase III Trial of Coenzyme Q10 in Mitochondrial Disease	PHASE3	COMPLETED
Effect of Montelukast Versus Co Enzyme in Sepsis	PHASE2/PHASE3	COMPLETED
Coenzyme Q10 as a Symptomatic Treatment in Parkinson's Disease	PHASE3	COMPLETED
Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder	PHASE2	WITHDRAWN
A Study of Bezafibrate in Mitochondrial Myopathy	PHASE2	COMPLETED
Trial of Nicotinamide Riboside and Co-enzyme Q10 in Chronic Kidney Disease	PHASE2	COMPLETED
Testing the Combination of MLN4924 (Pevonedistat), Carboplatin, and Paclitaxel in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) Who Have Previously Been Treated With Immunotherapy	PHASE2	ACTIVE_NOT_RECRUITING
Parkinson's Disease Treatment With Coenzyme Q10	PHASE2	COMPLETED
Does Clinical Treatment of Mitochondrial Dysfunction Impact Autism Spectrum Disorder (ASD)?	PHASE1	UNKNOWN
Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine	nan	COMPLETED
Tissue Sample Study for Mitochondrial Disorders	nan	ENROLLING_BY_INVITATION
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)	nan	RECRUITING
The Natural History of Mitochondrial Diseases	nan	RECRUITING
Mitoquines in COPD	nan	UNKNOWN
MITOMICS : a Multi-OMICS Approach for the Diagnosis of Mitochondrial Diseases	nan	RECRUITING
Evaluation of Impact of Disease and Visual Disability on Quality of Life and Loss of Independence of Patients Living in France With Leber's Hereditary Optic Neuropathy (LHON) Through Qualitative and Quantitative Data Collection	nan	COMPLETED
Identification of Large-Scale Mutations of POLG Gene by QMPSF in Patients With Mitochondrial DNA Instability.	nan	UNKNOWN
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes	nan	NOT_YET_RECRUITING
GDF-15 as a Biomarker for Mitochondrial Disease	nan	COMPLETED
Natural History in Primary Mitochondrial Myopathies	nan	RECRUITING
Identification of New Candidate Genes in Patients With Mitochondrial Disease by High Resolution Chromosome Analysis on DNA Chip	nan	COMPLETED
Diagnostic Odyssey Survey 2	nan	COMPLETED
Nicotinamide Riboside and Mitochondrial Biogenesis	nan	COMPLETED
Assessing the Role of Mitochondrial Dysfunction in Primary Progressive Multiple Sclerosis	nan	UNKNOWN
The Genetics of Diabetes in Southern California Chinese Americans	nan	WITHDRAWN
Calf Muscle Strength in Mitochondrial Diseases	nan	COMPLETED
Impact of Iron Deficiency and Its Correction on Mitochondrial Metabolism of the Cardiomyocyte (MitoCardioFer)	nan	COMPLETED
Gastrointestinal Dysfunction in Children Affected With Mitochondrial Disorders	nan	COMPLETED
Survey on Supplement Use in Mitochondrial Disease	nan	COMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a NDUFS8 binder may also engage these)

Protein	Name	Similarity
Q0MQI3	—	1.000	Q0MQI3 →
P0CB98	—	1.000	P0CB98 →
P0CB97	—	1.000	P0CB97 →
Q60HE3	—	1.000	Q60HE3 →
Q0MQI2	—	0.999	Q0MQI2 →
P42028	—	0.999	P42028 →
Q8K3J1	—	0.998	Q8K3J1 →
Q9VF27	—	0.970	Q9VF27 →
Q12644	—	0.968	Q12644 →
O21233	—	0.958	O21233 →
Q5LPS9	—	0.954	Q5LPS9 →
Q1GTK7	—	0.951	Q1GTK7 →
Q2G5Z4	—	0.951	Q2G5Z4 →
Q2NA74	—	0.944	Q2NA74 →
Q22619	—	0.943	Q22619 →
Q28T58	—	0.942	Q28T58 →
Q1GIM9	—	0.938	Q1GIM9 →
Q42599	—	0.938	Q42599 →
Q0APY2	—	0.937	Q0APY2 →
B6ISX3	—	0.937	B6ISX3 →
A8LIV0	—	0.936	A8LIV0 →
Q5RDD3	—	0.936	Q5RDD3 →
Q9FX83	—	0.935	Q9FX83 →
Q6UPE1	—	0.933	Q6UPE1 →
Q163R7	—	0.933	Q163R7 →
Q2KIG0	—	0.933	Q2KIG0 →
Q16134	—	0.932	Q16134 →
P55931	—	0.932	P55931 →
A3PIX9	—	0.932	A3PIX9 →
Q3J3F0	—	0.932	Q3J3F0 →