Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.39 |
| ▸ | HTT | P42858 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | ALPL | P05186 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28010208 | 0.81 | ALDH1A1 (0.41) | ALDH1A1HTTMAPTUSP2CYP1A2 | |
| SCHEMBL11243516 | 0.75 | HCAR2 (0.51) | HTTMAPTCYP2C19ATMKMT2A | |
| SCHEMBL10353860 | 0.74 | NPC1 (0.46) | ALDH1A1MAPTCYP1A2LMNAGAA | |
| SCHEMBL19330810 | 0.74 | GSR (0.49) | KMT2AHSD17B10 | |
| SCHEMBL11728908 | 0.74 | KMT2A (0.58) | ALDH1A1MAPTLMNAKMT2AMEN1 | |
| SCHEMBL11623274 | 0.73 | KDM4E (0.41) | HTTMAPTLMNAGAAHPGD | |
| SCHEMBL28135125 | 0.72 | MAPT (0.41) | ALDH1A1HTTMAPTCYP3A4ATM | |
| SCHEMBL19367484 | 0.71 | KCNH2 (0.39) | ALDH1A1HTTMAPTUSP2CYP1A2 | |
| SCHEMBL18752325 | 0.71 | ALDH1A1 (0.37) | ALDH1A1HTTMAPTUSP2CYP1A2 | |
| SCHEMBL23437875 | 0.71 | GSK3B (0.52) | HTTMAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4354026-A | 3-Chloro-6-(pyridinyl)-pyridazines | STERLING DRUG INC. (US) | 1982-10-12 | — | — | US | disclosed |
| US-4346221-A | Preparation of 4-amino-6-(pyridinyl)-3(2H)-pyridazinones from 6-(pyridinyl)-3(2H)-pyridazinones | STERLING DRUG INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4338446-A | Di-(lower-alkyl)hydroxy-[2-oxo-2-(pyridinyl)ethyl]-propanedioates | STERLING DRUG INC. (US) | 1982-07-06 | — | — | US | disclosed |
| US-4337253-A | 4,5-Dihydro-2-methyl-6-(4-pyridinyl)-3(2H)-pyridazinone and its use as a cardiotonic | STERLING DRUG INC. (US) | 1982-06-29 | — | — | US | disclosed |
| US-4305943-A | 4-Amino-6-(pyridinyl)-3(2H)-pyridazinones and their use as cardiotonics | STERLING DRUG INC. (US) | 1981-12-15 | — | — | US | disclosed |
| US-4304776-A | 4-Substituted-6-(pyridinyl)-3(2h)-pyridazinones and their use as intermediates and cardiotonics | STERLING DRUG INC. (US) | 1981-12-08 | — | — | US | disclosed |
| US-4304777-A | 6-(Pyridinyl)-3(2H)-pyridazinones and their use as cardiotonics | STERLING DRUG INC. (US) | 1981-12-08 | — | — | US | disclosed |
| US-4304775-A | 3-Hydrazino-6-(pyridinyl) pyridazines and cardiotonic use thereof | STERLING DRUG INC. (US) | 1981-12-08 | — | — | US | disclosed |