Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.32 |
| ▸ | WNT3A | P56704 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1857947 | 0.83 | HCAR2 (0.55) | HCAR2ATMSMYD3CTSBCYP2C9 | |
| SCHEMBL906183 | 0.80 | HCAR2 (0.58) | HCAR2ATMSMYD3CYP2C9CYP2C19 | |
| SCHEMBL26308881 | 0.75 | HCAR2 (0.62) | HCAR2ATMSMYD3CYP2C9CYP2C19 | |
| SCHEMBL17819609 | 0.75 | HCAR2 (0.62) | HCAR2ATMSMYD3CYP2C9CYP2C19 | |
| SCHEMBL11240574 | 0.75 | ALDH1A1 (0.39) | ATMCYP2C9CYP2C19HTTKMT2A | |
| SCHEMBL1203317 | 0.74 | HCAR2 (0.60) | HCAR2ATMSMYD3CYP2C9CYP2C19 | |
| SCHEMBL11728908 | 0.74 | KMT2A (0.58) | RAB9ACTNNB1WNT3AKMT2ATHRB | |
| Bromide SCHEMBL17504050 | 0.73 | HCAR2 (0.58) | HCAR2ATMSMYD3CYP2C9CYP2C19 | |
| SCHEMBL3932662 | 0.72 | PLOD2 (0.56) | HCAR2CTNNB1WNT3AKMT2ATHRB | |
| SCHEMBL21240973 | 0.71 | HCAR2 (0.56) | HCAR2ATMSMYD3CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4354026-A | 3-Chloro-6-(pyridinyl)-pyridazines | STERLING DRUG INC. (US) | 1982-10-12 | — | — | US | disclosed |
| US-4346221-A | Preparation of 4-amino-6-(pyridinyl)-3(2H)-pyridazinones from 6-(pyridinyl)-3(2H)-pyridazinones | STERLING DRUG INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4338446-A | Di-(lower-alkyl)hydroxy-[2-oxo-2-(pyridinyl)ethyl]-propanedioates | STERLING DRUG INC. (US) | 1982-07-06 | — | — | US | disclosed |
| US-4337253-A | 4,5-Dihydro-2-methyl-6-(4-pyridinyl)-3(2H)-pyridazinone and its use as a cardiotonic | STERLING DRUG INC. (US) | 1982-06-29 | — | — | US | disclosed |
| US-4305943-A | 4-Amino-6-(pyridinyl)-3(2H)-pyridazinones and their use as cardiotonics | STERLING DRUG INC. (US) | 1981-12-15 | — | — | US | disclosed |
| US-4304776-A | 4-Substituted-6-(pyridinyl)-3(2h)-pyridazinones and their use as intermediates and cardiotonics | STERLING DRUG INC. (US) | 1981-12-08 | — | — | US | disclosed |
| US-4304777-A | 6-(Pyridinyl)-3(2H)-pyridazinones and their use as cardiotonics | STERLING DRUG INC. (US) | 1981-12-08 | — | — | US | disclosed |
| US-4304775-A | 3-Hydrazino-6-(pyridinyl) pyridazines and cardiotonic use thereof | STERLING DRUG INC. (US) | 1981-12-08 | — | — | US | disclosed |