Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.42 |
| ▸ | FNTA | P49354 | 2/20 | 0.40 |
| ▸ | FNTB | P49356 | 2/20 | 0.40 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | EFNA1 | P20827 | 1/20 | 0.40 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11248546 | 0.85 | SRD5A2 (0.43) | GPBAR1SRD5A2FNTAFNTBNPC1L1 | |
| SCHEMBL11240580 | 0.85 | SRD5A2 (0.43) | GPBAR1SRD5A2FNTAFNTBNPC1L1 | |
| SCHEMBL11243498 | 0.84 | SRD5A2 (0.59) | GPBAR1SRD5A2FNTAFNTBAKR1B10 | |
| SCHEMBL11243490 | 0.84 | SRD5A2 (0.59) | GPBAR1SRD5A2FNTAFNTBAKR1B10 | |
| SCHEMBL11242975 | 0.78 | CYP17A1 (0.50) | GPBAR1SRD5A2FNTAFNTBACHE | |
| SCHEMBL11242981 | 0.78 | CYP17A1 (0.50) | GPBAR1SRD5A2FNTAFNTBACHE | |
| SCHEMBL11253127 | 0.76 | SRD5A1 (0.39) | SRD5A2ACHESRD5A1 | |
| SCHEMBL11253131 | 0.76 | SRD5A1 (0.39) | SRD5A2ACHESRD5A1 | |
| SCHEMBL11235256 | 0.75 | CYP19A1 (0.51) | GPBAR1SRD5A2LMNAKMT2AHSD17B10 | |
| SCHEMBL11235253 | 0.75 | CYP19A1 (0.51) | GPBAR1SRD5A2LMNAKMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4317817-A | SKIN DISORDERS; ACEME; ENZYME INHIBITORS | RICHARDSON-MERRELL INC. (US) | 1982-03-02 | — | — | US | disclosed |