Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 3/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.60 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.60 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.60 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.60 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.60 |
| ▸ | DRD3 | P35462 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | GLA | P06280 | 2/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.59 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3453702 | 0.82 | KDM4E (0.56) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL14369110 | 0.82 | ADRA1A (0.70) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL7794600 | 0.82 | ADRA1A (0.64) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL11568720 | 0.81 | KDM4E (0.55) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL11574238 | 0.81 | KDM4E (0.56) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL7797849 | 0.81 | ADRA1A (0.63) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL7787706 | 0.80 | KDM4E (0.73) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL31187488 | 0.80 | KDM4E (0.82) | ADRA1AADRA1BKDM4EALDH1A1HPGD | |
| SCHEMBL11082909 | 0.79 | ADRA1A (0.64) | ADRA1AADRA1B | |
| SCHEMBL11776489 | 0.79 | ADRA1A (0.66) | ADRA1DADRA1AADRA1BADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0004389-B1 | 4-AMINO-6,7-DIMETHOXY QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AND A PHARMACEUTICAL COMPOSITION | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1982-04-07 | — | — | EP | claimed |
| US-4230706-A | Antihypertensive quinazoline compounds | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1980-10-28 | — | — | US | claimed |
| EP-0004389-A2 | 4-Amino-6,7-dimethoxy quinazoline derivatives, process for their preparation, their use and a pharmaceutical composition | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1979-10-03 | — | — | EP | claimed |
| JP-54128581-A | — | — | None | — | — | JP | disclosed |
| EP-0004389-B1 | 4-AMINO-6,7-DIMETHOXY QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AND A PHARMACEUTICAL COMPOSITION | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1982-04-07 | — | — | EP | disclosed |
| US-4230706-A | Antihypertensive quinazoline compounds | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1980-10-28 | — | — | US | disclosed |
| JP-S54128581-A | NOVEL QUINAZOLINE DERIVATIVE AND ITS PREPARATION | SUMITOMO CHEM CO LTD | 1979-10-05 | — | — | JP | disclosed |
| EP-0004389-A2 | 4-Amino-6,7-dimethoxy quinazoline derivatives, process for their preparation, their use and a pharmaceutical composition | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1979-10-03 | — | — | EP | disclosed |