Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.54 |
| ▸ | HTR1A | P08908 | 5/20 | 0.54 |
| ▸ | HTR2A | P28223 | 5/20 | 0.54 |
| ▸ | HTR2C | P28335 | 1/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.54 |
| ▸ | HRH1 | P35367 | 1/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL512097 | 0.99 | DRD2 (0.53) | DRD2HTR1AHTR2AHTR2CADRA1A | |
| Hydrochloric Acid SCHEMBL294921 | 0.97 | HTR1A (0.57) | DRD2HTR1AHTR2AHTR2CADRA1A | |
| SCHEMBL299639 | 0.91 | DRD2 (0.56) | DRD2HTR1AHTR2AHTR2CADRA1A | |
| SCHEMBL4660526 | 0.88 | DRD2 (0.53) | DRD2HTR1AHTR2AHTR2CADRA1A | |
| SCHEMBL295076 | 0.84 | HTR1A (0.59) | DRD2HTR1AHTR2AHTR2CADRA1A | |
| SCHEMBL294684 | 0.83 | DRD2 (0.59) | DRD2HTR1AHTR2AHTR2CADRA1A | |
| SCHEMBL299572 | 0.83 | DRD2 (0.58) | DRD2HTR1AHTR2AHTR2CADRA1A | |
| SCHEMBL13663785 | 0.83 | DRD2 (0.58) | DRD2HTR1AHTR2AHTR2CADRA1A | |
| SCHEMBL4660522 | 0.82 | DRD2 (0.54) | DRD2HTR1AHTR2AHTR2CADRA1A | |
| SCHEMBL299610 | 0.82 | DRD2 (0.57) | DRD2HTR1AHTR2AHTR2CADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2287162-B1 | Derivatives of 4-piperazin-1-yl-4-benzo[b]thiophene suitable for the treatment of CNS disorders | OTSUKA PHARMA CO LTD (JP) | 2012-05-09 | — | — | EP | disclosed |
| EP-2287161-B1 | Derivatives of 4-piperazin-1-yl-4-benzo[b]thiophene suitable for the treatment of CNS disorders | OTSUKA PHARMA CO LTD (JP) | 2012-05-09 | — | — | EP | disclosed |
| EP-1919907-B9 | HETEROCYCLIC COMPOUND | OTSUKA PHARMA CO LTD (JP) | 2012-01-18 | — | — | EP | disclosed |
| EP-2287162-A1 | Derivatives of 4-piperazin-1-yl-4-benzo[b]thiophene suitable for the treatment of cns disorders | Otsuka Pharmaceutical Co., Ltd. (JP) | 2011-02-23 | — | — | EP | disclosed |
| EP-2287161-A1 | Derivatives of 4-piperazin-1-yl-4-benzo[b]thiophene suitable for the treatment of cns disorders | Otsuka Pharmaceutical Co., Limited (JP) | 2011-02-23 | — | — | EP | disclosed |
| EP-1919907-B1 | HETEROCYCLIC COMPOUND | OTSUKA PHARMA CO LTD (JP) | 2011-02-23 | — | — | EP | disclosed |
| EP-2284169-A1 | Derivatives of 4-piperazin-1-yl-4-benzo[b]thiophene suitable for the treatment of CNS disorders | Otsuka Pharmaceutical Co., Limited (JP) | 2011-02-16 | — | — | EP | disclosed |