SCHEMBL11241246

SCHEMBL11241246

COc1cccc2cc(C(=O)O)c(Nc3ccccc3O)nc12

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.47
ALDH1A1 P00352 2/20 0.47
HPGD P15428 2/20 0.47
HSD17B10 Q99714 2/20 0.46
ABCG2 Q9UNQ0 1/20 0.46
KMT2A Q03164 3/20 0.46
MEN1 O00255 2/20 0.46
POLB P06746 1/20 0.46
PDE10A Q9Y233 1/20 0.46
CA12 O43570 1/20 0.45
CA1 P00915 1/20 0.45
CA2 P00918 1/20 0.45
CA3 P07451 1/20 0.45
CA4 P22748 1/20 0.45
CA6 P23280 1/20 0.45
CA5A P35218 1/20 0.45
CA7 P43166 1/20 0.45
CA9 Q16790 1/20 0.45
CA14 Q9ULX7 1/20 0.45
CA5B Q9Y2D0 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL11240701 0.76 LCK (0.52) KDM4EALDH1A1HPGDHSD17B10
SCHEMBL7566381 0.73 KDM4E (0.55) KDM4EALDH1A1HPGDHSD17B10KMT2A
SCHEMBL21227040 0.69 KDM4E (0.47) KDM4EALDH1A1HPGDHSD17B10KMT2A
SCHEMBL4478341 0.68 CDC25B (0.52) KDM4EALDH1A1HPGDKMT2AMEN1
SCHEMBL9650028 0.68 NQO2 (0.47) KDM4EALDH1A1HPGDHSD17B10KMT2A
SCHEMBL8207252 0.67 KDM4E (0.77) KDM4EALDH1A1HPGDHSD17B10KMT2A
SCHEMBL29620158 0.67 ALDH1A1 (0.77) KDM4EALDH1A1HPGDHSD17B10KMT2A
SCHEMBL8206713 0.67 ALDH1A1 (0.77) KDM4EALDH1A1HPGDHSD17B10KMT2A
SCHEMBL26980980 0.67 TP53 (0.59) KDM4EALDH1A1HPGDHSD17B10KMT2A
SCHEMBL2025173 0.67 KMT2A (0.74) KDM4EALDH1A1HPGDHSD17B10KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4343804-A 4-Amino-3-quinolinecarboxylic acids and esters-antisecretory anti-ulcer compounds A. H. ROBINS COMPANY, INC. (US) 1982-08-10 US disclosed