Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 3/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11233199 | 0.89 | CYP11B1 (0.52) | CYP11B1CYP11B2KMT2AMEN1ALDH1A1 | |
| SCHEMBL11252441 | 0.89 | CYP11B1 (0.47) | CYP11B1CYP11B2KMT2AMEN1ALDH1A1 | |
| SCHEMBL11238541 | 0.88 | ALDH1A1 (0.39) | CYP11B1CYP11B2KMT2AMEN1ALDH1A1 | |
| SCHEMBL11246571 | 0.88 | CYP11B1 (0.51) | CYP11B1CYP11B2KMT2AMEN1ALDH1A1 | |
| SCHEMBL11248376 | 0.88 | CYP11B1 (0.46) | CYP11B1CYP11B2KMT2AMEN1ALDH1A1 | |
| SCHEMBL11243207 | 0.87 | CYP11B1 (0.48) | CYP11B1CYP11B2KMT2AMEN1ALDH1A1 | |
| SCHEMBL11231027 | 0.87 | CYP11B1 (0.50) | CYP11B1CYP11B2KMT2AMEN1ALDH1A1 | |
| SCHEMBL11260518 | 0.87 | CYP11B1 (0.46) | CYP11B1CYP11B2KCNH2 | |
| SCHEMBL11242164 | 0.85 | POLB (0.42) | CYP11B1CYP11B2KMT2AMEN1ALDH1A1 | |
| SCHEMBL11239107 | 0.82 | CYP19A1 (0.48) | CYP11B1CYP11B2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0049565-A2 | Derivatives of substituted N-alkylimidazoles, their preparation and pharmaceutical compositions containing them | SYNTEX (U.S.A.) INC. (US) | 1982-04-14 | — | — | EP | disclosed |
| US-4321272-A | Derivatives of substituted N-alkylimidazoles | SYNTEX (U.S.A.) INC. (US) | 1982-03-23 | — | — | US | disclosed |