Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | NPY1R | P25929 | 2/20 | 0.32 |
| ▸ | KIF18A | Q8NI77 | 12/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | FSHR | P23945 | 1/20 | 0.31 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.31 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL503769 | 0.85 | KCNH2 (0.33) | SCN9AKCNH2NPY1RKIF18AGSK3B | |
| SCHEMBL13688205 | 0.81 | KCNQ2 (0.39) | KCNH2KIF18AGSK3BDYRK1ATSHR | |
| SCHEMBL113294 | 0.80 | NPY1R (0.44) | KCNH2NPY1R | |
| SCHEMBL112996 | 0.80 | HRH4 (0.38) | KCNH2NPY1R | |
| SCHEMBL503794 | 0.80 | SCN9A (0.38) | SCN9AKCNH2NPY1RKIF18AGSK3B | |
| SCHEMBL504532 | 0.80 | — | — | |
| SCHEMBL13012098 | 0.80 | SCN9A (0.35) | SCN9ANPY1RKIF18ATSHRFSHR | |
| SCHEMBL962961 | 0.80 | NPY1R (0.50) | KCNH2NPY1RKIF18A | |
| SCHEMBL963958 | 0.79 | KCNH2 (0.37) | KCNH2NPY1RKIF18AGSK3BDYRK1A | |
| SCHEMBL113691 | 0.74 | KIF18A (0.37) | KIF18ATSHRFSHRKCNQ2KCNQ3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424860-A1 | HETEROARYLTHIOMETHYL PYRIDINE DERIVATIVE | MSD K.K. (JP) | 2012-03-07 | — | — | EP | disclosed |
| US-20120028970-A1 | HETEROARYLTHIOMETHYL PYRIDINE DERIVATIVE | MSD K.K. (JP) | 2012-02-02 | — | — | US | disclosed |
| WO-2010126163-A1 | HETEROARYLTHIOMETHYL PYRIDINE DERIVATIVE | BANYU PHARMACEUTICAL CO.,LTD. (JP) | 2010-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028970-A1 | HETEROARYLTHIOMETHYL PYRIDINE DERIVATIVE | AR, NR5A1, ARL1 | SCN9A 3772/4885KCNH2 3202/4885NPY1R 354/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.