Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | FSHR | P23945 | 1/20 | 0.31 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.31 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.31 |
| ▸ | NPY1R | P25929 | 2/20 | 0.31 |
| ▸ | KIF18A | Q8NI77 | 4/20 | 0.31 |
| ▸ | CCR5 | P51681 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL112418 | 0.85 | SCN9A (0.34) | KCNH2SCN9AGSK3BDYRK1ATSHR | |
| SCHEMBL503774 | 0.84 | — | — | |
| SCHEMBL503773 | 0.84 | — | — | |
| SCHEMBL503794 | 0.84 | SCN9A (0.38) | KCNH2SCN9AGSK3BDYRK1ATSHR | |
| SCHEMBL962961 | 0.80 | NPY1R (0.50) | KCNH2NPY1RKIF18A | |
| SCHEMBL13688205 | 0.80 | KCNQ2 (0.39) | KCNH2GSK3BDYRK1ATSHRFSHR | |
| SCHEMBL504000 | 0.79 | NPY1R (0.36) | KCNH2NPY1R | |
| SCHEMBL13012098 | 0.79 | SCN9A (0.35) | SCN9ATSHRFSHRKCNQ3KCNQ2 | |
| SCHEMBL963958 | 0.78 | KCNH2 (0.37) | KCNH2GSK3BDYRK1ATSHRFSHR | |
| SCHEMBL113691 | 0.75 | KIF18A (0.37) | TSHRFSHRKCNQ3KCNQ2KIF18A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120028970-A1 | HETEROARYLTHIOMETHYL PYRIDINE DERIVATIVE | MSD K.K. (JP) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028970-A1 | HETEROARYLTHIOMETHYL PYRIDINE DERIVATIVE | AR, NR5A1, ARL1 | KCNH2 3202/4885SCN9A 3772/4885GSK3B 2528/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.