Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.38 |
| ▸ | TNKS | O95271 | 1/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 3/20 | 0.36 |
| ▸ | CA2 | P00918 | 3/20 | 0.36 |
| ▸ | CA4 | P22748 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1124199 | 1.00 | KDM4E (0.40) | KDM4ELMNAHCAR2HDAC3HDAC4 | |
| SCHEMBL194887 | 0.69 | — | — | |
| SCHEMBL27770149 | 0.68 | MEN1 (0.57) | KDM4ELMNAHDAC6ALDH1A1CYP3A4 | |
| SCHEMBL16479485 | 0.68 | KDM4E (0.44) | KDM4ELMNAHCAR2HDAC3HDAC4 | |
| SCHEMBL29175969 | 0.68 | KDM4E (0.43) | KDM4ELMNAHCAR2HDAC3HDAC4 | |
| SCHEMBL15758064 | 0.68 | KDM4E (0.44) | KDM4ELMNAHCAR2HDAC3HDAC4 | |
| SCHEMBL14721174 | 0.68 | KDM4E (0.44) | KDM4ELMNAHCAR2HDAC3HDAC4 | |
| SCHEMBL27973196 | 0.67 | ALDH1A1 (0.41) | KDM4ELMNAALDH1A1KMT2AMAPT | |
| SCHEMBL2575865 | 0.67 | HDAC1 (0.69) | KDM4ELMNAHCAR2HDAC3HDAC4 | |
| SCHEMBL2575867 | 0.67 | HDAC1 (0.69) | KDM4ELMNAHCAR2HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102816133-A | 5-chloro-1,2,3-thiadiazole-4-acrylic derivatives, and preparation method and application thereof | UNIV NANKAI | 2012-12-12 | — | — | CN | claimed |
| CN-102816133-B | 5-chloro-1,2,3-thiadiazole-4-acrylic derivatives, and preparation method and application thereof | UNIV NANKAI | 2014-07-02 | — | — | CN | disclosed |
| CN-102816133-A | 5-chloro-1,2,3-thiadiazole-4-acrylic derivatives, and preparation method and application thereof | UNIV NANKAI | 2012-12-12 | — | — | CN | disclosed |
| US-20110281869-A1 | TETRAHYDROISOQUINOLINES AS ANTIMALARIAL AGENTS | AISSAOUI HAMED (FR) | 2011-11-17 | — | — | US | disclosed |
| EP-2282996-A1 | TETRAHYDROISOQUINOLINES AS ANTIMALARIAL AGENTS | Actelion Pharmaceuticals Ltd. (CH) | 2011-02-16 | — | — | EP | disclosed |
| WO-2009141782-A1 | TETRAHYDROISOQUINOLINES AS ANTIMALARIAL AGENTS | ACTELION PHARMACEUTICALS LTD (CH) | 2009-11-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110281869-A1 | TETRAHYDROISOQUINOLINES AS ANTIMALARIAL AGENTS | QTRT2, RECQL, QTRT1 | KDM4E 1537/4885LMNA 1932/4885HCAR2 2378/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.