Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 3/20 | 0.35 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.35 |
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11309660 | 0.87 | HRH3 (0.37) | KDM2BHRH3SLC6A4SIGMAR1CYP3A4 | |
| Hydrochloric Acid SCHEMBL11253560 | 0.85 | KDM2B (0.38) | KDM2BHRH3SLC6A4 | |
| SCHEMBL11229680 | 0.83 | DRD1 (0.39) | KDM2BCYP3A4CYP2D6 | |
| SCHEMBL11089320 | 0.77 | DRD2 (0.38) | HRH3SLC6A4CYP3A4CYP2D6 | |
| Bromide SCHEMBL11245427 | 0.74 | DRD2 (0.53) | CYP3A4CYP2D6 | |
| SCHEMBL11238141 | 0.71 | DRD1 (0.43) | SLC6A4CYP3A4CYP2D6 | |
| SCHEMBL11283177 | 0.71 | DRD2 (0.56) | CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL11361769 | 0.70 | DRD1 (0.42) | SLC6A4CYP3A4CYP2D6 | |
| SCHEMBL11216105 | 0.70 | DRD1 (0.50) | HRH3SLC6A4CYP3A4CYP2D6 | |
| Bromide SCHEMBL11236726 | 0.68 | DRD2 (0.38) | KDM2BCYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4328153-A | HYPOTENSIVE AGENT | SMITH KLINE CORPORATION (US) | 1982-05-04 | — | — | US | disclosed |