SCHEMBL11243013

SCHEMBL11243013

C(=C/c1ccccc1)\Cn1cncn1

nearest known ligand 0.51

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 8/20 0.51
KMT2A Q03164 2/20 0.46
HSP90AA1 P07900 1/20 0.45
KDM4E B2RXH2 2/20 0.42
LMNA P02545 2/20 0.42
HDAC3 O15379 1/20 0.42
HDAC4 P56524 1/20 0.42
HDAC1 Q13547 1/20 0.42
HDAC7 Q8WUI4 1/20 0.42
HDAC2 Q92769 1/20 0.42
HDAC10 Q969S8 1/20 0.42
HDAC11 Q96DB2 1/20 0.42
HDAC8 Q9BY41 1/20 0.42
HDAC6 Q9UBN7 1/20 0.42
HDAC9 Q9UKV0 1/20 0.42
HDAC5 Q9UQL6 1/20 0.42
MEN1 O00255 1/20 0.40
MAPT P10636 1/20 0.40
MMP12 P39900 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9729237 1.00 CYP19A1 (0.51) CYP19A1KMT2AHSP90AA1KDM4ELMNA
SCHEMBL31415770 0.82 HDAC1 (0.46) CYP19A1KMT2AHSP90AA1HDAC3HDAC4
SCHEMBL6442620 0.82 CYP19A1 (0.55) CYP19A1KMT2AHSP90AA1KDM4ELMNA
SCHEMBL6953906 0.82 POLB (0.48) CYP19A1KDM4EHDAC1HDAC8MAPT
SCHEMBL6953913 0.82 POLB (0.48) CYP19A1KDM4EHDAC1HDAC8MAPT
SCHEMBL11036061 0.74 CYP19A1 (0.47) CYP19A1KMT2AHSP90AA1KDM4ELMNA
SCHEMBL11036059 0.74 CYP19A1 (0.47) CYP19A1KMT2AHSP90AA1KDM4ELMNA
SCHEMBL31696327 0.74 HDAC3 (0.46) KDM4ELMNAHDAC3HDAC4HDAC1
SCHEMBL8927087 0.69 CYP19A1 (0.41) CYP19A1KMT2AKDM4EMEN1
SCHEMBL8347428 0.69 TBXAS1 (0.68) CYP19A1KMT2ALMNAMEN1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4315017-A Triazole derivatives BASF AKTIENGESELLSCHAFT (DE) 1982-02-09 US disclosed
EP-0008651-B1 DERIVATIVES OF TRIAZOLE, PROCESS FOR THEIR PRODUCTION AND INSECTICIDES CONTAINING THEM BASF Aktiengesellschaft (DE) 1981-10-14 EP disclosed
EP-0008651-A1 Derivatives of triazole, process for their production and insecticides containing them BASF Aktiengesellschaft (DE) 1980-03-19 EP disclosed