Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 6/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.52 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1124319 | 1.00 | HDAC1 (0.52) | HDAC1HDAC2HCAR2MAPK1KMT2A | |
| SCHEMBL11744369 | 0.88 | HDAC1 (0.46) | HDAC1HDAC2HCAR2MAPK1KMT2A | |
| SCHEMBL11744376 | 0.88 | HDAC1 (0.46) | HDAC1HDAC2HCAR2MAPK1KMT2A | |
| SCHEMBL4887101 | 0.85 | HDAC1 (0.52) | HDAC1HDAC2HCAR2MAPK1KMT2A | |
| SCHEMBL4887097 | 0.85 | HDAC1 (0.52) | HDAC1HDAC2HCAR2MAPK1KMT2A | |
| SCHEMBL12497241 | 0.78 | HCAR2 (0.42) | HDAC1HDAC2HCAR2MAPK1KMT2A | |
| SCHEMBL12497242 | 0.78 | HCAR2 (0.42) | HDAC1HDAC2HCAR2MAPK1KMT2A | |
| SCHEMBL4013209 | 0.78 | KDM4E (0.45) | HDAC1HDAC2HCAR2MAPK1KMT2A | |
| SCHEMBL4013207 | 0.78 | KDM4E (0.45) | HDAC1HDAC2HCAR2MAPK1KMT2A | |
| SCHEMBL9467437 | 0.77 | NPC1 (0.45) | HDAC1HDAC2HCAR2MAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4053618-A | ANTILIPOLYTIC | ROUSSEL-UCLAF (FR) | 1977-10-11 | — | — | US | claimed |
| US-20110281869-A1 | TETRAHYDROISOQUINOLINES AS ANTIMALARIAL AGENTS | AISSAOUI HAMED (FR) | 2011-11-17 | — | — | US | disclosed |
| EP-2282996-A1 | TETRAHYDROISOQUINOLINES AS ANTIMALARIAL AGENTS | Actelion Pharmaceuticals Ltd. (CH) | 2011-02-16 | — | — | EP | disclosed |
| WO-2009141782-A1 | TETRAHYDROISOQUINOLINES AS ANTIMALARIAL AGENTS | ACTELION PHARMACEUTICALS LTD (CH) | 2009-11-26 | — | — | WO | disclosed |
| EP-0074229-A1 | Triazole gastric anti-secretory agents | PFIZER INC. (US) | 1983-03-16 | — | — | EP | disclosed |
| US-4172137-A | 5-Thiazole-alkylamines used as antilipolytics | ROUSSEL UCLAF (FR) | 1979-10-23 | — | — | US | disclosed |
| US-4073919-A | Hypolipemiant compositions and methods | ROUSSEL UCLAF (FR) | 1978-02-14 | — | — | US | disclosed |
| US-4053618-A | ANTILIPOLYTIC | ROUSSEL-UCLAF (FR) | 1977-10-11 | — | — | US | disclosed |
| US-4032643-A | ANTILIPOLYTIC AGENTS, VASODILATION, ANTIBRADYKINETIC AGENTS | ROUSSEL-UCLAF (FR) | 1977-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110281869-A1 | TETRAHYDROISOQUINOLINES AS ANTIMALARIAL AGENTS | QTRT2, RECQL, QTRT1 | HDAC1 1796/4885HDAC2 1618/4885HCAR2 2378/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.