Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 11/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 11/20 | 0.52 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 10/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 10/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 10/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 10/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 10/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 10/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 10/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4887097 | 1.00 | HDAC1 (0.52) | HDAC1HDAC2HCAR2GLATDP1 | |
| SCHEMBL1124319 | 0.85 | HDAC1 (0.52) | HDAC1HDAC2HCAR2KMT2AALDH1A1 | |
| SCHEMBL1124322 | 0.85 | HDAC1 (0.52) | HDAC1HDAC2HCAR2KMT2AALDH1A1 | |
| SCHEMBL29169246 | 0.80 | GLA (0.36) | HDAC1HDAC2GLATDP1MAPT | |
| SCHEMBL29169282 | 0.80 | GLA (0.36) | HDAC1HDAC2GLATDP1MAPT | |
| SCHEMBL12499239 | 0.78 | HDAC1 (0.47) | HDAC1HDAC2HCAR2MAPTALDH1A1 | |
| SCHEMBL4886203 | 0.77 | HDAC1 (0.43) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL11744376 | 0.77 | HDAC1 (0.46) | HDAC1HDAC2HCAR2MAPTKMT2A | |
| SCHEMBL4886196 | 0.77 | HDAC1 (0.43) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL11744369 | 0.77 | HDAC1 (0.46) | HDAC1HDAC2HCAR2MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080267942-A1 | BENZAZEPIN-2(1H)-ONE DERIVATIVES | PFIZER LIMITED (GB) | 2008-10-30 | — | — | US | disclosed |
| US-20080103130-A1 | 7-hydroxy-6-{[1-methyl-3-(1,3-thiazol-5-yl)propyl]amino}-4,5,6,7-tetrahydroimidazo[4,5,1-jk][1]benzazepin-2(1H)-one; agonists at the beta-2 adrenoceptor; feed additives for livestock animals; improving meat yield or meat quality | PFIZER LIMITED (GB) | 2008-05-01 | — | — | US | disclosed |
| EP-0125094-B1 | HERBICIDAL CYCLOHEXANE-1,3-DIONE DERIVATIVES | ICI AUSTRALIA LIMITED (AU) | 1991-04-24 | — | — | EP | disclosed |
| US-4715884-A | MONOCOTYLEDONOUS WEEDS IN DICOTYLEDONOUS CROPS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1987-12-29 | — | — | US | disclosed |
| US-4704157-A | MONOCOTYLEDONOUS WEEDS IN DICOTYLEDONOUS CROPS | CI AUSTRALIA LTD. (AU) | 1987-11-03 | — | — | US | disclosed |
| US-4604132-A | Herbicidal 5-(hetero-substituted) cyclohexane-1,3-dione derivatives | ICI AUSTRALIA LIMITED (AU) | 1986-08-05 | — | — | US | disclosed |
| EP-0125094-A2 | Herbicidal cyclohexane-1,3-dione derivatives | ICI AUSTRALIA LIMITED (AU) | 1984-11-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080103130-A1 | 7-hydroxy-6-{[1-methyl-3-(1,3-thiazol-5-yl)propyl]amino}-4,5,6,7-tetrahydroimidazo[4,5,1-jk][1]benzazepin-2(1H)-one; agonists at the beta-2 adrenoceptor; feed additives for livestock animals; improving meat yield or meat quality | ADRB2, ADRB1, ADRA2C | HDAC1 1929/4885HDAC2 745/4885HCAR2 442/4885 |
| US-20080267942-A1 | BENZAZEPIN-2(1H)-ONE DERIVATIVES | ADRB2, ADRB1, ADRA2C | HDAC1 1362/4885HDAC2 250/4885HCAR2 440/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.