SCHEMBL11243299

SCHEMBL11243299

O=C(O)[C@@H]1CC(CCc2ccccc2)CN1

nearest known ligand 0.54

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ARG1 P05089 1/20 0.54
KDM4E B2RXH2 1/20 0.51
MAPT P10636 1/20 0.51
HIF1A Q16665 1/20 0.51
F2 P00734 1/20 0.46
GRIK1 P39086 5/20 0.43
DPP4 P27487 1/20 0.41
HRH3 Q9Y5N1 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP2D6 P10635 1/20 0.41
ALOX15 P16050 1/20 0.41
CYP2C19 P33261 1/20 0.41
SLC1A3 P43003 1/20 0.41
SLC1A2 P43004 1/20 0.41
SLC1A1 P43005 1/20 0.41
GLB1 P16278 1/20 0.40
GBA2 Q9HCG7 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11243295 1.00 ARG1 (0.54) ARG1KDM4EMAPTHIF1AF2
SCHEMBL11239409 0.91 ARG1 (0.51) ARG1KDM4EMAPTHIF1AF2
SCHEMBL19432303 0.91 ARG1 (0.51) ARG1KDM4EMAPTHIF1AF2
SCHEMBL11239411 0.91 ARG1 (0.51) ARG1KDM4EMAPTHIF1AF2
SCHEMBL27444952 0.85 F2 (0.48) KDM4EMAPTHIF1AF2DPP4
SCHEMBL19292680 0.84 HRH3 (0.54) ARG1F2GRIK1HRH3CYP1A2
SCHEMBL1706921 0.84 HRH3 (0.54) ARG1F2GRIK1HRH3CYP1A2
SCHEMBL199034 0.84 HRH3 (0.54) ARG1F2GRIK1HRH3CYP1A2
SCHEMBL22536533 0.84 HRH3 (0.54) ARG1F2GRIK1HRH3CYP1A2
SCHEMBL199035 0.84 HRH3 (0.54) ARG1F2GRIK1HRH3CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4316905-A HYPOTENSIVE AGENTS E. R. SQUIBB & SONS, INC. (US) 1982-02-23 US disclosed