Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.49 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GRK2 | P25098 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | NQO2 | P16083 | 1/20 | 0.45 |
| ▸ | PORCN | Q9H237 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | GLS | O94925 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11391291 | 0.81 | HTT (1.00) | HTTLMNAATAD2CECR2TSHR | |
| Nefiracetam SCHEMBL135856 | 0.79 | HTT (0.66) | HTTLMNAMAP4K4ATAD2CECR2 | |
| SCHEMBL11240697 | 0.78 | HTT (0.57) | HTTLMNAMAP4K4ATAD2CECR2 | |
| SCHEMBL6775638 | 0.77 | HTT (0.71) | HTTMAP4K4ATAD2CECR2TSHR | |
| SCHEMBL17896872 | 0.77 | HTT (0.71) | HTTLMNAMAP4K4ATAD2CECR2 | |
| SCHEMBL4191223 | 0.76 | ALDH1A1 (0.60) | HTTALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL1355628 | 0.75 | HTT (0.74) | HTTLMNAMAP4K4ATAD2CECR2 | |
| SCHEMBL7437681 | 0.75 | HTT (0.60) | HTTLMNAATAD2CECR2ALDH1A1 | |
| SCHEMBL5197138 | 0.75 | HTT (0.68) | HTTLMNATSHRALDH1A1POLB | |
| Dupracetam SCHEMBL1814646 | 0.74 | TSHR (0.63) | HTTLMNAATAD2CECR2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4324787-A | 2-Oxo-1-pyrrolidineacetic acid compounds and their medicinal use | TROPONWERKE GMBH & CO., KG (DE) | 1982-04-13 | — | — | US | disclosed |
| EP-0003029-B1 | NEW 2-OXO-1-PYRROLIDINE ACETIC ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM AND PROCESS FOR THEIR PREPARATION | Troponwerke GmbH & Co. KG (DE) | 1980-12-10 | — | — | EP | disclosed |
| EP-0003029-A2 | New 2-oxo-1-pyrrolidine acetic acid derivatives, process for their preparation, medicaments containing them and process for their preparation | Troponwerke GmbH & Co. KG (DE) | 1979-07-25 | — | — | EP | disclosed |