Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | NQO2 | P16083 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GRK2 | P25098 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.42 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.42 |
| ▸ | SLC8A1 | P32418 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11251993 | 0.82 | LMNA (0.58) | HTTLMNANQO2TSHRMAPK14 | |
| SCHEMBL11243322 | 0.78 | HTT (0.68) | HTTLMNANQO2TSHRMAPK14 | |
| SCHEMBL11242670 | 0.76 | HTT (0.59) | HTTLMNANQO2TSHRALDH1A1 | |
| SCHEMBL1397958 | 0.73 | HTT (0.56) | HTTLMNANQO2TSHRCTDSP1 | |
| SCHEMBL9202868 | 0.73 | HTT (0.56) | HTTLMNANQO2TSHRKMT2A | |
| SCHEMBL11512524 | 0.73 | HTT (0.82) | HTTLMNATSHRMAPK14ALDH1A1 | |
| SCHEMBL11391291 | 0.73 | HTT (1.00) | HTTLMNATSHRALDH1A1MAPT | |
| Dupracetam SCHEMBL1814646 | 0.72 | TSHR (0.63) | HTTLMNATSHRALDH1A1KMT2A | |
| SCHEMBL11245716 | 0.72 | HTT (0.55) | HTTLMNANQO2TSHRMAPK1 | |
| SCHEMBL9208885 | 0.72 | HTT (0.55) | HTTLMNANQO2TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4324787-A | 2-Oxo-1-pyrrolidineacetic acid compounds and their medicinal use | TROPONWERKE GMBH & CO., KG (DE) | 1982-04-13 | — | — | US | disclosed |
| EP-0003029-B1 | NEW 2-OXO-1-PYRROLIDINE ACETIC ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM AND PROCESS FOR THEIR PREPARATION | Troponwerke GmbH & Co. KG (DE) | 1980-12-10 | — | — | EP | disclosed |
| EP-0003029-A2 | New 2-oxo-1-pyrrolidine acetic acid derivatives, process for their preparation, medicaments containing them and process for their preparation | Troponwerke GmbH & Co. KG (DE) | 1979-07-25 | — | — | EP | disclosed |