Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPG | P10696 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | BLM | P54132 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CASP1 | P29466 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11243612 | 1.00 | ALPG (0.43) | ALPGAKR1B1CYP1A2CYP2C9KDM4E | |
| SCHEMBL11255541 | 0.90 | ALPG (0.44) | ALPGAKR1B1KDM4EALDH1A1HPGD | |
| SCHEMBL11255538 | 0.90 | ALPG (0.44) | ALPGAKR1B1KDM4EALDH1A1HPGD | |
| SCHEMBL11245407 | 0.89 | AKR1B1 (0.51) | ALPGAKR1B1TTR | |
| SCHEMBL11245411 | 0.89 | AKR1B1 (0.51) | ALPGAKR1B1TTR | |
| SCHEMBL11254681 | 0.89 | P2RX3 (0.46) | ALPGAKR1B1KDM4EALDH1A1HPGD | |
| SCHEMBL11254686 | 0.89 | P2RX3 (0.46) | ALPGAKR1B1KDM4EALDH1A1HPGD | |
| SCHEMBL11255503 | 0.88 | ALPG (0.43) | ALPGAKR1B1CYP1A2KDM4EALDH1A1 | |
| SCHEMBL11255509 | 0.88 | ALPG (0.43) | ALPGAKR1B1CYP1A2KDM4EALDH1A1 | |
| SCHEMBL11249635 | 0.87 | ALPG (0.43) | ALPGAKR1B1CYP1A2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4341780-A | Substituted pyrido [1,2-a] pyrimidines useful as anti-allergic, anti-ulcer and anti-diabetic agents | FARMITALIA CARLO ERBA S.P.A. (IT) | 1982-07-27 | — | — | US | claimed |
| US-4341780-A | Substituted pyrido [1,2-a] pyrimidines useful as anti-allergic, anti-ulcer and anti-diabetic agents | FARMITALIA CARLO ERBA S.P.A. (IT) | 1982-07-27 | — | — | US | disclosed |
| US-4310526-A | Substituted 6,7-methylene pyrido[1,2-a]pyrimidines useful as anti-allergic and anti-ulcer agents | FARMITALIA CARLO ERBA S.P.A. (IT) | 1982-01-12 | — | — | US | disclosed |