Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 4/20 | 0.55 |
| ▸ | RAD52 | P43351 | 4/20 | 0.47 |
| ▸ | PDE5A | O76074 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11250277 | 0.77 | APP (0.60) | APPPDE5ACYP1A2CYP2D6ALDH1A1 | |
| SCHEMBL11665848 | 0.76 | APP (0.63) | APPPDE5ALMNAKDM4ESMN1; SMN2 | |
| SCHEMBL11249235 | 0.76 | APP (0.56) | APPPDE5ACYP1A2CYP2D6USP2 | |
| SCHEMBL11244506 | 0.76 | APP (0.54) | APPRAD52PDE5ACYP1A2CYP2D6 | |
| SCHEMBL23723479 | 0.75 | KMT2A (0.70) | APPPDE5ACYP1A2CYP2D6USP2 | |
| SCHEMBL11240444 | 0.75 | APP (0.55) | APPRAD52PDE5ACYP1A2CYP2D6 | |
| SCHEMBL11242191 | 0.74 | APP (0.54) | APPRAD52PDE5ACYP1A2CYP2D6 | |
| SCHEMBL15502283 | 0.74 | ACP1 (0.68) | APPPDE5AMEN1KMT2ALMNA | |
| SCHEMBL3113286 | 0.73 | CYP1A2 (0.70) | APPPDE5ACYP1A2CYP2D6USP2 | |
| SCHEMBL8897898 | 0.72 | CYP1A2 (0.68) | APPPDE5ACYP1A2CYP2D6USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4323680-A | 4-Aminoquinazoline compounds useful as agricultural fungicides | SANKYO COMPANY LIMITED (JP) | 1982-04-06 | — | — | US | disclosed |
| US-4213987-A | 4-AMINOQUINAZOLINES | SANKYO COMPANY LIMITED (JP) | 1980-07-22 | — | — | US | disclosed |