Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 4/20 | 0.54 |
| ▸ | PDE5A | O76074 | 1/20 | 0.50 |
| ▸ | RAD52 | P43351 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.45 |
| ▸ | PGK1 | P00558 | 1/20 | 0.45 |
| ▸ | ACP1 | P24666 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | CASP6 | P55212 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11243542 | 0.93 | APP (0.56) | APPPDE5ARAD52CYP1A2CYP3A4 | |
| SCHEMBL11250277 | 0.91 | APP (0.60) | APPPDE5ACYP1A2CYP3A4CYP2C19 | |
| SCHEMBL11255663 | 0.87 | APP (0.51) | APPPDE5ARAD52CYP1A2CYP3A4 | |
| SCHEMBL11253738 | 0.86 | APP (0.54) | APPPDE5ACYP1A2CYP3A4CYP2C19 | |
| SCHEMBL11264589 | 0.83 | APP (0.63) | APPPDE5ARAD52CYP1A2CYP3A4 | |
| SCHEMBL11252777 | 0.81 | LMNA (0.59) | APPCYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL11254484 | 0.80 | APP (0.53) | APPPDE5ARAD52CYP1A2CYP3A4 | |
| SCHEMBL11251275 | 0.78 | GBA1 (0.63) | APPPDE5ARAD52CYP1A2CYP3A4 | |
| SCHEMBL15502283 | 0.78 | ACP1 (0.68) | APPPDE5AKDM4EMEN1KMT2A | |
| SCHEMBL23723479 | 0.77 | KMT2A (0.70) | APPPDE5ACYP1A2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4323680-A | 4-Aminoquinazoline compounds useful as agricultural fungicides | SANKYO COMPANY LIMITED (JP) | 1982-04-06 | — | — | US | disclosed |
| US-4213987-A | 4-AMINOQUINAZOLINES | SANKYO COMPANY LIMITED (JP) | 1980-07-22 | — | — | US | disclosed |